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Moumoujus

QUATERNIUM-24.

Avoid CAS 32426-11-2 / ANTIMICROBIAL, ANTISTATIC, SURFACTANT - CLEANSING

QUATERNIUM-24 is a complex quaternary ammonium compound primarily utilized for its antimicrobial, antistatic, and surfactant properties. It is a cationic surfactant found in a broad array of personal care, pharmaceutical, and cleaning products.

Summary

Antimicrobial Antistatic Surfactant

Science

Mechanism of Action

As an amphiphilic cationic surfactant, QUATERNIUM-24 functions by reducing interfacial tension through self-assembly, which enables its cleansing and antimicrobial actions. Its antimicrobial efficacy stems from its ability to denature cellular proteins and disrupt cell membranes. In the context of adverse effects, QACs like QUATERNIUM-24 can trigger skin changes via the production of reactive oxygen species and activation of the arachidonic acid pathway, contributing to irritant or allergic contact dermatitis.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No specific clinical studies demonstrating beneficial skin outcomes or effective concentrations for QUATERNIUM-24 were identified, indicating an absence of efficacy claims to be overrepresented ('dusted').

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Conflicts

  • Potentially incompatible with ingredients that may lead to the formation of N-nitroso compounds, a concern observed with certain quaternary ammonium compounds.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

The Cosmetic Ingredient Review (CIR) has not directly assessed QUATERNIUM-24. However, related Quaternary Ammonium Compounds (QACs) have specific safety limitations, for instance, Quaternium-15 is recommended below 0.2% due to formaldehyde release, and Quaternium-26 should avoid use in products where N-nitroso compounds might form. QUATERNIUM-24 is identified as a 'Candidate Chemical' under California's Safer Consumer Products Regulations, signaling potential harm to individuals or the environment. Exposure to QACs, in general, is associated with dermal, respiratory, and immune toxicities, including skin irritation, sensitization, and various forms of dermatitis. EWG rates QUATERNIUM-24 with 'LOW_MODERATE' for Allergies & Immunotoxicity and 'SOME' for Skin Allergies & Irritation.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to a lack of established skin benefits and significant safety concerns, including high risks for irritation and sensitization, QUATERNIUM-24 is not recommended for precision skincare formulations.

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