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Moumoujus

QUATERNIUM-22.

Valuable CAS 51812-80-7 / 82970-95-4 / ANTISTATIC, FILM FORMING, HAIR CONDITIONING

Quaternium-22 is a cationic quaternary ammonium compound that functions primarily as a skin and hair conditioning agent. Its positive charge facilitates adherence to negatively charged protein surfaces, forming a protective film that imparts emollient properties.

Summary

Antistatic Film-forming Hair conditioning Skin conditioning

Science

Mechanism of Action

This ingredient operates as a cationic compound, meaning its positive charge allows it to substantively bind to the mildly negatively charged proteins present on the skin and hair surface. This electrostatic interaction results in the formation of a thin, conditioning film that helps to smooth, soften, and protect the skin.

Research

Clinical Evidence

Medium confidence
Effective range 0.5–5%
Optimal

5%

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 2 – 12
0 7 14

Stability

The cationic charge of Quaternium-22's nitrogen atom remains stable across a broad pH range (2-12). However, at high pH levels, its water solubility may be reduced.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
5%
Sensitization risk Low

The CIR Expert Panel has deemed Quaternium-22 safe for cosmetic use at concentrations up to 5% solids, noting its poor absorption through the skin. Strict limits are imposed on specific impurities, such as 3-dimethylaminopropylamine (0.2%) and ethylene chlorohydrin (0.008%), to mitigate the potential formation of carcinogenic nitrosamines in the final product.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Quaternium-22 is a valuable ingredient, particularly for its effective film-forming and conditioning properties on both skin and hair, with a low irritancy profile and established safety up to 5%.

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