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Moumoujus

PYRUS BRETSCHNEIDERI FRUIT EXTRACT.

Valuable / SKIN CONDITIONING

Pyrus Bretschneideri Fruit Extract, sourced from the Chinese white pear, is a precision botanical ingredient known for its comprehensive antioxidant and anti-inflammatory capabilities. It actively defends the skin against environmental stressors and oxidative damage, while promoting overall skin health and resilience.

Summary

Antioxidant Anti-inflammatory UV Damage Repair/Protection Skin Barrier Support Soothing Hydrating Antimicrobial

Science

Mechanism of Action

This extract functions by delivering a broad spectrum of antioxidant and anti-inflammatory actions. Its rich flavonoid content effectively neutralizes free radicals and reduces the production of reactive oxygen and nitrogen species (RONS), demonstrating up to 50% inhibition in keratinocytes at 25 mg/L in vitro. It significantly decreases UVB-induced IL-6 production and suppresses the mRNA expression of UVA-induced inflammatory cytokines, including IL-1β, IL-6, and TNF-α. Furthermore, it helps reduce UVA-induced skin cell death, inhibits mitogen-activated protein kinase phosphorylation, and contributes to strengthening the skin's barrier function. Specific isolated compounds like quercitrin, 2β,19α-dihydroxy ursolic acid, and α-amyrin also provide anti-inflammatory and moderate anti-microbial benefits.

Research

Clinical Evidence

Medium confidence
Effective range 3–4%
Optimal

N/A

Key findings

  1. 01 In vitro, the extract at 25 mg/L reduced reactive oxygen and nitrogen species (RONS) by 50% and decreased UVB-induced IL-6 production in keratinocytes. A concentration of 10 mg/L also showed a reduction in UVB-induced IL-6.
  2. 02 Lotion formulations containing 3-4% of the peel extract exhibited antioxidant properties and maintained physical stability over a 1-week period.
  3. 03 An unspecified pear water extract significantly reduced UVA-induced skin cell death, inhibited the expression of UVA-induced cytokines (IL-1β, IL-6, TNF-α), and mitigated oxidative stress in skin cells in vitro. In vivo pretreatment in hairless mice effectively reduced transepidermal water loss (TEWL), inflammation, redness, and dryness.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 7
0 7 14

Stability

Formulations, specifically lotions, containing Pyrus Bretschneideri Fruit Extract demonstrate stability within a pH range of 4.5–7.0, aligning with the physiological pH of human skin and minimizing irritation potential. Extraction using 70% ethanol at room temperature is recommended to preserve active metabolites.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific CIR, SCCS, or FDA safety assessment for Pyrus Bretschneideri Fruit Extract was identified in the available research data.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Pyrus Bretschneideri Fruit Extract is a valuable botanical offering robust antioxidant, anti-inflammatory, and UV protection benefits, making it an excellent candidate for formulations targeting skin resilience and overall health.

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