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PYRROLOQUINOLINE QUINONE ALLYL ESTER.

Valuable CAS 175429-96-6 / ANTIOXIDANT

Pyrroloquinoline Quinone Allyl Ester (PQQAE) is an advanced antioxidant known for its multi-faceted benefits in skin health. It actively neutralizes free radicals, enhances mitochondrial energy production for cellular repair, and demonstrates significant anti-inflammatory and skin barrier strengthening properties.

Summary

Antioxidant Anti-aging Anti-inflammatory Skin barrier support Depigmentation Hydration Mitochondrial support DNA repair

Science

Mechanism of Action

PQQAE operates as a potent antioxidant, effectively scavenging free radicals generated by both internal metabolic processes and external environmental stressors like UV radiation and pollution. It is crucial for optimizing mitochondrial function, supporting efficient cellular energy production vital for skin renewal. Furthermore, PQQAE activates genes involved in mitochondrial biogenesis, increasing cellular energy for improved repair. Its anti-inflammatory action is evidenced by its ability to reduce pro-inflammatory molecules such as interleukin-6 (IL-6) and C-reactive protein (CRP). It also fortifies the skin barrier by stimulating the synthesis of essential lipids like ceramides, thereby enhancing hydration and minimizing transepidermal water loss. For hyperpigmentation, PQQAE is presumed to reduce melanin production via tyrosinase inhibition, and it aids in DNA repair by activating sirtuins.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

PQQAE is not typically associated with 'dusting' at sub-efficacious concentrations for marketing claims.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The allyl ester modification significantly enhances the stability of PQQAE compared to the parent PQQ molecule, rendering it more suitable for topical formulations. This modification also contributes to reduced potential for skin irritation.

Synergies

  • Chlorogenic acid
  • Methyl gentisate (for hyperpigmentation)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Pyrroloquinoline Quinone Allyl Ester has not been directly reviewed by CIR or SCCS. Its parent compound, Pyrroloquinoline Quinone (PQQ) disodium salt, holds a Generally Recognized As Safe (GRAS) designation from the FDA for specific food applications at concentrations up to 0.05%. Topical application of PQQAE in clinical studies has shown good tolerability, with adverse events being mild and transient. One instance of moderate, temporary eye burning was reported upon contact. The allyl ester modification was specifically implemented to improve product stability and minimize potential skin irritation compared to PQQ itself.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Pyrroloquinoline Quinone Allyl Ester is a valuable ingredient, offering broad-spectrum benefits from potent antioxidant and anti-inflammatory action to clinically demonstrated improvements in hyperpigmentation and overall skin photodamage.

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