Science
Mechanism of Action
Pyroligneous Acids Extracts exert their beneficial effects by selectively inactivating pathogenic microorganisms responsible for skin and other infections, while preserving the skin's beneficial commensal microbiota. Its wound-healing capabilities are driven by promoting wound contraction, accelerating tissue regeneration, downregulating inflammatory pathways (TGF-β/SMAD) in diabetic wounds, and upregulating key wound-healing and anti-inflammatory proteins such as Akt, FAK, RhoA, and Rac-1. The extract's rich phenolic content also confers robust antioxidant protection, while its organic acids and phenolic substances contribute significantly to its strong antimicrobial efficacy.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Pyroligneous acid is a complex aqueous solution, typically comprising 80-90% water and 10-20% organic compounds. It exhibits good solubility in water, alcohol, and propylene glycol. Its natural pH is notably acidic, generally ranging from 2.6 to 4.4.
Conflicts
- Rubber materials (can lead to cracking, swelling, loss of strength, and leaching of plasticizers due to its corrosive nature).
Safety
Safety Profile
Pyroligneous Acids Extracts are inherently acidic (pH 2.6-4.4) due to high concentrations of volatile organic acids like acetic and formic acid, imparting mild corrosive properties. Formulations must distinguish it from coal tar and monitor for a low formaldehyde content (less than 5 ppm W/V) as a safety consideration.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Pyroligneous Acids Extracts offer significant antimicrobial and wound-healing benefits, making it a valuable ingredient when formulated precisely to manage its inherent acidity and potential for trace compounds.
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