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PYROGLUTAMYLAMIDOETHYL INDOLE.

Valuable CAS - / SKIN PROTECTING

Pyroglutamylamidoethyl Indole is an innovative chronopeptide engineered to support the skin's natural circadian rhythm and defense mechanisms. It exhibits significant potential in modulating sebum production and addressing acne, alongside offering anti-aging benefits.

Anti-aging Sebum Regulation Acne Prevention Skin Protection

Science

This anti-aging chronopeptide functions by mimicking the activation of circadian genes, a process naturally stimulated by sun exposure, which is crucial for maintaining proper skin biorhythms. It is also purported to stimulate the skin's innate defense system and may contribute to the skin's capacity for Vitamin D synthesis.


Research

Medium confidence
Effective range 0.05–50%
Optimal

N/A

Key findings

  1. 01 Demonstrated excellent effects in inhibiting sebum secretion, alleviating skin shining, and preventing and treating acne across a concentration range of 0.05% to 50.0% by weight.

Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH N/A
0 7 14

Stability

No specific optimal pH range for the stability of Pyroglutamylamidoethyl Indole has been identified.


Safety

CIR Status
Not reviewed
Sensitization risk Unknown

This ingredient has not undergone review by the Cosmetic Ingredient Review (CIR) panel. Specific GHS classifications, hazard statements, and detailed oral, dermal, or inhalation toxicity data are currently unavailable. It is recognized by the FDA with a Unique Ingredient Identifier (UNII) 9V365LE3DX.


Your Skin

No Normal
No Dry
Yes Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Valuable

Pyroglutamylamidoethyl Indole presents as a valuable active ingredient, particularly for oily and acne-prone skin types, with promising anti-aging and skin defense properties, pending more comprehensive independent safety and efficacy data.


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