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PYROGLUTAMYL DIPEPTIDE-30 AMIDE.

Insufficient Data CAS 24305-27-9 / SKIN CONDITIONING

PYROGLUTAMYL DIPEPTIDE-30 AMIDE is a synthetic peptide ingredient characterized by an N-terminal pyroglutamyl modification. This specific chemical structure can influence its physicochemical properties within a formulation.

Summary

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 7
0 7 14

Stability

Peptides generally demonstrate susceptibility to chemical and physical instability in aqueous solutions. Common degradation pathways include hydrolysis (acid-catalyzed at pH 1-3, or at N-terminal serine residues at pH 5-6), deamidation, β-elimination, and oxidation. Physical instabilities may involve adsorption and aggregation. The N-terminal pyroglutamyl modification in this specific peptide is noted to potentially increase hydrophobicity, suggesting improved solubility and stability within acidic to neutral pH ranges (3-7), and reduced solubility in more basic environments.

Conflicts

  • Extreme pH values (below 3 or above 7) due to increased risk of hydrolysis and epimerization.
  • Oxidizing agents, which can lead to chemical degradation.
  • Certain metal ions, capable of inducing oxidation or disulfide exchange reactions.
  • High temperatures, which can accelerate degradation processes.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) expert panel has not yet reviewed the safety of PYROGLUTAMYL DIPEPTIDE-30 AMIDE for cosmetic use.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Due to a complete lack of information regarding its mechanism of action, clinical efficacy, and skin benefits, the value of PYROGLUTAMYL DIPEPTIDE-30 AMIDE in skincare formulations cannot be currently determined.

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