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PYRIDYLOXIDE T-BUTYLNITRONE.

Insufficient Data CAS 66893-81-0 / ANTIOXIDANT

PYRIDYLOXIDE T-BUTYLNITRONE (POBN) is a nitrone compound known for its robust antioxidant and spin-trapping properties. It effectively scavenges various short-lived free radicals, particularly non-lipid radicals, which contributes to mitigating oxidative stress in cosmetic applications.

Antioxidant Free Radical Scavenger

Science

PYRIDYLOXIDE T-BUTYLNITRONE functions primarily by acting as a spin-trapping antioxidant, directly reacting with and neutralizing highly reactive free radicals. It is particularly effective at trapping non-lipid radicals, such as hydroxyl radicals, converting them into more stable, less damaging forms. Insights from related nitrone compounds suggest a potential to inhibit pro-inflammatory gene expression and offer broader protection against oxidative cellular damage.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH N/A
0 7 14

Stability

PYRIDYLOXIDE T-BUTYLNITRONE is supplied as a solid. Its class of nitrone compounds is generally noted for advantageous stability, making them suitable for long-term antioxidant needs in cosmetic formulations.


Safety

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessments by established cosmetic regulatory bodies such as the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS) are available for PYRIDYLOXIDE T-BUTYLNITRONE. While it possesses a UNII (2140SM8Q5O) and CAS number (66893-81-0) in the FDA Global Substance Registration System (GSRS), suppliers typically designate it as 'for research use only,' suggesting limited comprehensive safety evaluation for consumer cosmetic applications.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Insufficient Data

While PYRIDYLOXIDE T-BUTYLNITRONE demonstrates a promising mechanism as a potent antioxidant, its current 'research use only' classification and the absence of comprehensive consumer cosmetic safety and clinical efficacy data indicate insufficient information for a confident recommendation in formulated products.


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