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PYRIDOXINE GLYCYRRHETINATE.

Valuable CAS 3390-81-6 / SKIN CONDITIONING

PYRIDOXINE GLYCYRRHETINATE is an advanced ester combining Pyridoxine (Vitamin B6) and Glycyrrhetinic Acid, formulated to leverage the potent benefits of both components. This oil-soluble derivative is designed to enhance skin penetration and stability, delivering comprehensive support for skin health and function. It targets multiple concerns including inflammation, oxidative stress, barrier compromise, and hyperpigmentation.

Summary

Skin Conditioning Antioxidant Anti-inflammatory Sebum Control Brightening Skin Barrier Support

Science

Mechanism of Action

This ester synergistically delivers Pyridoxine, which promotes epidermal health by increasing profilaggrin mRNA expression and subsequent filaggrin protein production, critical for a robust skin barrier. Pyridoxine also acts as an antioxidant via the Nrf2 pathway, helps suppress melanosome phagocytosis by keratinocytes to prevent pigmented spots, and offers sebum-regulating, rebalancing, and antibacterial effects. Glycyrrhetinic Acid, renowned for its significant anti-inflammatory properties, complements these actions. The esterification enhances stability and skin compatibility, allowing for effective delivery of these multifaceted benefits.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Pyridoxine was shown to increase profilaggrin mRNA and filaggrin protein in normal human epidermal keratinocytes, indicating strong barrier support.
  2. 02 Glycyrrhetinic Acid demonstrated no skin irritancy or sensitization in clinical tests at concentrations up to 6%.

Transparency

Dusting Analysis

Not commonly dusted

No data available to suggest common dusting practices or thresholds for this specific ingredient.

The Formula

Formulation

Solubility
Oil
Optimal pH 5 – 7
0 7 14

Stability

Optimal stability for its pyridoxine component is observed within a pH range of 5.0 to 7.0. Significant decomposition may occur below pH 3.0 or above pH 9.0. It is sensitive to high heat, prolonged light or UV exposure, and oxidizing agents, necessitating careful formulation and packaging to preserve efficacy. The ester form itself is engineered for improved stability and skin compatibility compared to water-soluble pyridoxine salts.

Conflicts

  • Strong alkaline conditions (pH > 9.0)
  • Strong acidic conditions (pH < 3.0)
  • High temperatures
  • Prolonged exposure to light or UV radiation
  • Oxidizing agents

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

While direct CIR assessment for PYRIDOXINE GLYCYRRHETINATE is not available, its components have established safety profiles. Glycyrrhetinic Acid and its related esters are deemed safe for use by the CIR Expert Panel. Pyridoxine HCl (Vitamin B6) is recognized as a skin-conditioning agent and is FDA-approved for dietary supplements. The low sensitization risk is inferred from the established safety of its constituent parts.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

PYRIDOXINE GLYCYRRHETINATE is a valuable, multi-functional ingredient offering significant benefits for skin barrier integrity, inflammation reduction, and overall skin health, suitable for a broad range of skin types and concerns.

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References

Sources