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PYRIDOXINE DICAPRYLATE.

Valuable CAS 106483-04-9 / ANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING

Pyridoxine Dicaprylate is a stable, lipid-soluble derivative of Vitamin B6, engineered for enhanced skin penetration and efficacy. It delivers potent antioxidant, anti-inflammatory, and sebum-regulating benefits, while also contributing to skin hydration and overall anti-aging processes.

Antioxidant Anti-inflammatory Sebum-regulating Hydrating Skin conditioning Anti-aging Hair conditioning Antistatic Pigmentation-preventing

Science

As a lipid-soluble derivative of pyridoxine (Vitamin B6), Pyridoxine Dicaprylate demonstrates superior percutaneous absorption and stability within formulations. It functions as a biological precursor, supporting active coenzymes involved in crucial metabolic reactions. On the skin, it exhibits robust antioxidant properties by neutralizing free radicals, which helps prevent collagen degradation, reduce inflammation, and mitigate signs of aging such as fine lines and dark spots. It possesses anti-inflammatory capabilities that soothe irritated skin and regulate sebum production, making it particularly beneficial for oily and acne-prone complexions. Furthermore, it enhances skin hydration by stimulating filaggrin expression and increasing Natural Moisturizing Factor (NMF) synthesis, contributing to a smooth, soft texture and a protective barrier against moisture loss. This ingredient also supports collagen synthesis and assists in preventing hyperpigmentation by modulating keratinocyte differentiation.


Research

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Studies on Pyridoxine Dipalmitate, a similar lipophilic Vitamin B6 derivative, indicate effectiveness at concentrations between 0.5% and 2.0% against skin roughness, acne, sunburns, skin inflammation, and seborrheic eczema.
  2. 02 Pyridoxine Dicaprylate is recognized for its efficacy in treating acne, rough skin, dandruff, and sunburn.
  3. 03 Pyridoxine Tris-Hexyldecanoate, another lipophilic ester of Vitamin B6, demonstrated improved skin hydration through enhanced filaggrin expression and increased Natural Moisturizing Factor (NMF) synthesis, exhibiting superior skin penetration compared to pure Pyridoxine.

Transparency

Not commonly dusted

The Formula

Solubility
Oil
Optimal pH 5 – 7
0 7 14

Stability

As a lipid-soluble derivative of Vitamin B6, Pyridoxine Dicaprylate exhibits enhanced stability against oxidation and heat compared to its hydrophilic counterpart. This stability ensures a prolonged shelf life, making it well-suited for oil-based formulations and lipophilic delivery systems.


Safety

CIR Status
Not reviewed
Sensitization risk Unknown

Pyridoxine Dicaprylate itself does not have specific GHS hazard statements reported. While Pyridoxine (Vitamin B6) in its raw form may cause skin and serious eye irritation, this derivative is designed for improved stability and skin compatibility. However, specific topical cosmetic safety assessments by regulatory bodies such as CIR, SCCS, or FDA are currently unavailable for Pyridoxine Dicaprylate.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Valuable

Pyridoxine Dicaprylate is a valuable, stable Vitamin B6 derivative offering multifaceted benefits for skin health, including antioxidant protection, sebum regulation, hydration enhancement, and anti-aging support.


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