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Moumoujus

PYRIDOXINE CYCLIC PHOSPHATE.

Valuable CAS 36944-85-1 / HAIR CONDITIONING, SKIN CONDITIONING

Pyridoxine Cyclic Phosphate is a stable, advanced derivative of Vitamin B6 (Pyridoxine), engineered for enhanced skin penetration and efficacy. It precisely targets common skin concerns such as excess sebum production, enlarged pores, and inflammatory responses, leading to comprehensive improvements in skin appearance and texture.

Summary

skin conditioning sebum control pore reduction anti-inflammatory soothing moisture retention

Science

Mechanism of Action

Applied topically, Pyridoxine Cyclic Phosphate efficiently permeates the skin's deeper layers, where it is hydrolyzed by endogenous enzymes into its active form, Pyridoxine. Its primary mechanism involves inhibiting the 5α-reductase enzyme, which consequently reduces dihydrotestosterone (DHT) quantities and significantly lessens sebum production. Furthermore, it modulates the skin's inflammatory cascade by reducing the production of pro-inflammatory interleukins IL-6 and IL-8 by keratocytes, thereby imparting significant anti-inflammatory and soothing effects.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In a 4-week clinical study, topical application significantly reduced pore size and facial shine. It improved oily skin appearance, texture, and facial shine by up to 56%, and reduced pore size by up to 55%.
  2. 02 Demonstrated significant anti-inflammatory and soothing effects, reducing skin redness, UV-induced inflammation, and irritation by lessening IL-6 and IL-8 pro-inflammatory interleukin production. It also enhances the skin's intrinsic moisture retention capabilities.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 6.5 – 8
0 7 14

Stability

As a stable derivative of Pyridoxine, this ingredient exhibits good stability under both sunlight and heat. It maintains excellent compatibility with other vitamins and offers improved skin penetration compared to its parent compound.

Synergies

  • other vitamins

Safety

Safety Profile

CIR Status
Safe as used
Max tested
2%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel affirms its safety, supported by a robust data profile, GRAS status, its endogenous nature, and the absence of positive alerts in toxicological studies. It is typically formulated at concentrations up to 2%. The FDA does not pre-approve cosmetic ingredients, and no specific SCCS opinion was found.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Pyridoxine Cyclic Phosphate is a valuable active ingredient for addressing oily, pore-prone, and sensitive skin concerns, demonstrating strong clinical efficacy in sebum and pore reduction alongside significant anti-inflammatory benefits, all within a well-established safety profile.

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