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PUNICA GRANATUM PERICARP EXTRACT.

Valuable CAS 84961-57-9 / SKIN CONDITIONING

Derived from the skin of pomegranates, Punica Granatum Pericarp Extract is a powerful antioxidant and anti-inflammatory ingredient. Rich in polyphenols, it actively combats oxidative stress, reduces visible signs of aging, and offers significant photoprotection, contributing to a more resilient and radiant complexion.

Summary

skin conditioning antioxidant anti-aging soothing anti-inflammatory photoprotection antibacterial

Science

Mechanism of Action

Punica Granatum Pericarp Extract exerts its multifaceted benefits primarily through its high concentration of polyphenols, flavonoids, ellagitannins, ellagic acid, and proanthocyanidins. These compounds function as potent antioxidants, neutralizing free radicals and preventing cellular damage that leads to premature skin aging. Its anti-inflammatory action works by modulating pathways that trigger sensitivity and reducing pro-inflammatory cytokines such as IL-1α, IL-1ra, IL-6, IL-8, and GM-CSF, thus calming irritated skin. Furthermore, it offers photoprotection against UVA-induced damage by inhibiting Matrix Metallopeptidase 1 (MMP-1), an enzyme responsible for collagen degradation, and contributes to reducing melanin production. The extract also demonstrates antibacterial properties and can enhance the utilization of retinoids while simultaneously mitigating their associated irritation.

Research

Clinical Evidence

High confidence
Effective range 0.001–10%
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.001%
Red flag below
0.001%

Punica Granatum Pericarp Extract is effectively functional at remarkably low concentrations. As demonstrated by a proprietary extract, a mere 0.001% can deliver significant anti-inflammatory and photoprotective benefits. Given its maximum safe concentration of 10%, formulators have ample room to achieve clinical efficacy, rendering dusting below functional levels highly unlikely for key benefits such as UVA protection and MMP-1 inhibition.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Ethanolic extracts of Punica granatum pericarp maintain over 80% total polyphenol stability for 2 months when stored at 4 °C, room temperature, or 45 °C. Pre-formulated extracts exhibit high stability for periods exceeding 3 months at 5 °C.

Synergies

  • Retinoids (enhances utilization, reduces irritation)

Conflicts

  • DMSO (not suitable as a cosmetic solvent)

Safety

Safety Profile

CIR Status
Safe as used
Max tested
10%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has affirmed Punica Granatum Pericarp Extract's safety for use in cosmetics under current practices and concentrations, up to 10%. Testing showed a tradename mixture containing 10% of the extract was non-irritating in an in vitro human epidermal model. Furthermore, a human single patch test with 20% of a 0.5% solids tradename mixture demonstrated no irritation. The FDA also recognizes essential oils, solvent-free oleoresins, and natural extracts from Punica granatum Linnaeus as Generally Recognized As Safe (GRAS) for food consumption.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Punica Granatum Pericarp Extract is a highly valuable ingredient for precision skincare, offering clinically supported anti-aging, antioxidant, anti-inflammatory, and photoprotective benefits with excellent safety and broad skin compatibility, even at low concentrations.

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