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Moumoujus

PULSATILLA SAPONIN.

Insufficient Data CAS 106577-41-7 / SKIN CONDITIONING

Pulsatilla saponin refers to a class of triterpenoid saponins derived from the Pulsatilla plant, recognized for their diverse biological activities. In skincare, this ingredient is explored for its potential anti-inflammatory, antioxidant, and antimicrobial properties, aiming to soothe irritated skin and support its protective barrier function.

Summary

Antimicrobial/antibacterial Antioxidant Skin-soothing Moisturizer/humectant Natural preservative Anti-inflammatory Sebum-regulating Skin barrier strengthening Anti-aging

Science

Mechanism of Action

Pulsatilla saponins exert anti-inflammatory effects by modulating key cellular pathways, including NF-κB and JAK1/STAT3, thereby reducing the expression of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. Additionally, they exhibit antimicrobial activity against common skin bacteria like *Staphylococcus aureus*, *Pseudomonas aeruginosa*, and *Escherichia coli*, alongside demonstrating antioxidant capacity. Extracts containing these saponins are also noted to help regulate sebum production, enhance skin hydration, and reinforce the skin's protective barrier, contributing to overall skin soothing and potentially anti-aging benefits.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Conflicts

  • Fresh Pulsatilla plant material due to severe irritancy and potential allergic reactions.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

Fresh Pulsatilla plant material is classified as 'LIKELY UNSAFE' for topical application, causing severe irritation, rash, inflammation, itching, and allergic reactions. Currently, there is insufficient reliable safety information from major cosmetic regulatory bodies (CIR, SCCS, FDA) to determine the safety profile of isolated Pulsatilla saponins for cosmetic skin application.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Pulsatilla saponin demonstrates promising *in vitro* and *in vivo* biological activities, including anti-inflammatory, antioxidant, and antimicrobial effects, a critical lack of comprehensive safety data for isolated saponins in cosmetic applications necessitates caution.

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