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Moumoujus

PULSATILLA KOREANA EXTRACT.

Valuable / SKIN CONDITIONING

Pulsatilla Koreana Extract is a botanical active renowned for its multi-faceted benefits, including potent anti-inflammatory and antimicrobial properties. It actively supports skin barrier function and helps soothe irritated skin, making it particularly beneficial for sensitive and reactive complexions.

Summary

anti-inflammatory antimicrobial soothing skin barrier support antioxidant astringent sebum regulation natural preservative

Science

Mechanism of Action

This extract operates through several key pathways to promote skin health. It significantly supports the skin's natural barrier by increasing essential protein levels like filaggrin, involucrin, and loricrin, crucial for maintaining skin integrity and hydration. Furthermore, Pulsatilla Koreana Extract inhibits the JAK/STAT inflammatory pathway, effectively suppressing inflammatory responses in keratinocytes. Its anti-inflammatory action also extends to modulating cytokine production, decreasing pro-inflammatory markers (IL-1β, IL-6, TNF-α) while elevating the anti-inflammatory cytokine IL-10. Beyond soothing, it exhibits broad-spectrum antimicrobial activity against common skin bacteria, including Propionibacterium acnes, and helps regulate sebum secretion, contributing to a balanced skin microflora and overall skin defense. Bioactive compounds such as flavonoids and saponins are believed to drive these diverse benefits.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Preclinical studies demonstrated that Pulsatilla Koreana Extract (PKN) alleviated atopic dermatitis-like symptoms in mice by restoring reduced protein levels of skin barrier factors (filaggrin, involucrin, loricrin) and inhibiting the JAK/STAT pathway. High concentrations of PKN extract significantly increased the expression of these proteins.
  2. 02 In a rat model, a methanol extract of Pulsatilla koreana significantly inhibited LPS-induced inflammatory responses, decreasing pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) and increasing the anti-inflammatory cytokine IL-10.
  3. 03 P. koreana extracts showed strong antimicrobial activities against Propionibacterium acnes, a primary bacterium associated with acne, as well as a wide range of other gram-negative and gram-positive bacteria.

Transparency

Dusting Analysis

Not commonly dusted

Data not available in research materials.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

Generally considered safe in cosmetic formulations at recommended concentrations. However, individuals with extremely sensitive skin should perform a patch test due to potential allergic reactions or irritation. There is a reported case of acute bullous irritant contact dermatitis caused by a Pulsatilla koreana extract. It is important to note that fresh Pulsatilla plant material is considered unsafe and can cause severe irritation upon direct skin application.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Pulsatilla Koreana Extract is a valuable botanical ingredient offering comprehensive benefits for various skin concerns, particularly anti-inflammatory, antimicrobial, and skin barrier support.

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