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PULMONARIA OFFICINALIS EXTRACT.

Valuable CAS 84604-09-1 / ASTRINGENT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

PULMONARIA OFFICINALIS EXTRACT, derived from Lungwort, is a multifaceted botanical ingredient celebrated for its potent antioxidant and anti-inflammatory properties. It actively protects skin from oxidative damage and can aid in brightening and conditioning, contributing to a refined and soothed complexion. Traditionally recognized for wound healing, it offers comprehensive skin support.

Summary

Antioxidant Skin-Conditioning Astringent Anti-inflammatory Skin Brightening Wound Healing

Science

Mechanism of Action

This extract demonstrates its antioxidant capacity by mitigating peroxynitrite-induced oxidative stress and boosting the non-enzymatic antioxidant defense system within the skin. Its anti-inflammatory action is primarily attributed to cyclooxygenase-2 (COX-2) inhibition. Beyond these, the extract acts as an astringent, helping to tighten and firm the skin, while also functioning as a skin conditioning agent to promote softness and smoothness. It further exhibits skin brightening potential through tyrosinase inhibition, a key enzyme in melanin production.

Research

Clinical Evidence

Medium confidence
Effective range 7.24–100%
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The extract's active components, including phenolic acids, anthocyanins, and flavonoids, contribute to its water solubility. The presence of mucilage can influence a formulation's texture and stability. Tannins, known for their astringent properties, may interact with certain formulation components such as iron or proteins, which should be considered during development.

Conflicts

  • Tannins in the extract may react with iron or proteins.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessments by CIR or SCCS for cosmetic use have been identified. However, cellular safety of the extracts (1-100 µg/mL) has been confirmed in experimental models involving blood platelets and peripheral blood mononuclear cells. Historically, it has been used externally in traditional medicine for various skin irritations. It is important to note that comprehensive safety studies and clinical trials for cosmetic applications are generally lacking, despite its listing in health product databases for pharmaceutical use in countries like Poland and Canada.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

PULMONARIA OFFICINALIS EXTRACT is a valuable botanical offering robust antioxidant and anti-inflammatory benefits, alongside skin conditioning and brightening properties, making it a promising ingredient for diverse skin concerns, though further comprehensive clinical safety data for cosmetic applications would enhance its profile.

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