Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

PUERARIA MIRIFICA CALLUS CULTURE EXTRACT.

Insufficient Data CAS - / ANTIOXIDANT, HAIR CONDITIONING, SKIN PROTECTING

Pueraria Mirifica Callus Culture Extract is a plant-derived ingredient, rich in phytoestrogens, cultivated for its potential to support skin's natural balance, promote cellular renewal, and offer protection against environmental stressors, ultimately enhancing skin's overall appearance and texture.

Summary

Antioxidant Skin Protecting Anti-aging Skin Firming Moisturizing Skin Brightening Cell Renewal Hair Conditioning

Science

Mechanism of Action

Operating at a cellular level, this extract is believed to help re-establish hormonal equilibrium within the skin, thereby stimulating dermal fibroblasts to enhance collagen synthesis and bolster elastin fiber integrity for improved skin resiliency. It actively mitigates collagen degradation by inhibiting matrix metalloproteinases (MMPs), and through the activation of estrogen receptors, it can increase skin thickness and firmness. Furthermore, it supports skin moisture retention, crucial for maintaining the integrity of the collagen matrix, revitalizes skin cell regeneration, and may regulate melanin synthesis to reduce the appearance of dark spots and hyperpigmentation.

Research

Clinical Evidence

Low confidence
Effective range ≥10 µg/mL%
Optimal

N/A

Key findings

  1. 01 At a concentration of 10 µg/mL, the extract demonstrated estrogenic activity equivalent to 1×10⁻¹⁰ M estradiol in an MCF-7 cell proliferation assay. However, treatment with a higher concentration (100 µg/mL) of the insoluble fraction led to cell growth suppression, highlighting the necessity for purification to remove potentially cytotoxic constituents.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Conflicts

  • Insoluble fractions within the extract may contain cytotoxic constituents and require thorough removal during the formulation process to ensure product safety and retain the desired estrogenic activity.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Pueraria Mirifica Callus Culture Extract has not undergone specific review by the Cosmetic Ingredient Review (CIR) Expert Panel. While Pueraria Mirifica root extract is generally considered safe, individual sensitivities or allergic reactions may occur. Given its phytoestrogenic compounds, some experts advise caution and recommend patch testing, especially for individuals with reactive or sensitive skin, as these compounds may interact with hormonal dermatologic conditions. An in vitro study indicated that a high concentration (100 µg/mL) of the *insoluble fraction* of the callus extract resulted in cell growth suppression, emphasizing the critical importance of purification to eliminate potentially toxic components in cosmetic formulations.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Pueraria Mirifica Callus Culture Extract shows promising in vitro phytoestrogenic activity for anti-aging and skin health benefits; however, more comprehensive clinical efficacy and safety data, alongside meticulous purification to remove cytotoxic insoluble fractions, are crucial for its confident inclusion in precision skincare.

Related

Similar Ingredients

Finding similar ingredients…