Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

PTEROCARPUS SANTALINUS STEM EXTRACT.

Valuable CAS 84650-41-9 / HAIR CONDITIONING

Pterocarpus Santalinus Stem Extract, derived from Red Sandalwood, is a potent botanical extract recognized for its significant antioxidant and anti-inflammatory capabilities. It works to soothe skin, mitigate oxidative stress, and support the appearance of a more even and refined complexion.

Summary

Antioxidant Anti-inflammatory Antimicrobial Soothing Refreshing Cooling Skin Tightening Moisturizing Blemish Reduction Anti-aging UV Protection Astringent Tonic

Science

Mechanism of Action

This extract operates through multifaceted pathways to bolster skin health. Its primary antioxidant activity is attributed to a rich composition of flavonoids, phenols, and polyphenolic compounds, which effectively scavenge free radicals. It demonstrates notable anti-inflammatory properties by inhibiting key inflammatory mediators such as β-hexosaminidase and histamine release, and by reducing the secretion of tumor necrosis factor-α, interleukin-4, and prostaglandin E2. Additionally, it exhibits antimicrobial effects against certain pathogens like *Escherichia coli* and *Aspergillus niger*, contributes to skin tightening, aids in moisture retention, and may help to diminish the appearance of scars, blemishes, and hyperpigmentation. The extract also shows preliminary indications of anti-aging and UV-B protective benefits.

Research

Clinical Evidence

Medium confidence
Effective range 0.1%–10%%
Optimal

N/A

Key findings

  1. 01 Antioxidant activity was robust, with a 0.1% concentration of methanol and ethanol extracts from bark and heartwood demonstrating significant DPPH radical inhibition of 83.4% and 79% respectively. Further studies on ethanolic extract revealed dose-dependent free radical scavenging, achieving 52% at 2.5%, 68% at 5%, and 75% at 10% concentration.
  2. 02 Topical gel formulations containing the extract effectively demonstrated anti-inflammatory effects in carrageenan-induced rat paw edema models and were confirmed to be free of skin irritation.
  3. 03 In a mouse model, Pterocarpus Santalinus extract suppressed atopic dermatitis-like skin lesions by regulating serum immunoglobulin E and G2a levels, alongside modulating T helper cell 1- and T helper cell 2-related messenger RNA expression.

Transparency

Dusting Analysis

Not commonly dusted

Based on current data, there is no indication that Pterocarpus Santalinus Stem Extract is subject to disproportionate marketing claims relative to its scientific substantiation.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Specific stability details or optimal pH range were not provided in the available research.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) and European Scientific Committee on Consumer Safety (SCCS) have not conducted specific safety assessments for Pterocarpus Santalinus Stem Extract. However, related ingredient 'Pterocarpus Santalinus Wood Extract' is rated 'LOW' for potential concerns like allergies and immunotoxicity by EWG Skin Deep, though with limited data. Clinical studies on topical gel formulations containing the extract reported no skin irritation, suggesting a favorable topical safety profile. A formally established 'safe as used' maximum concentration for skincare has not been identified.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Pterocarpus Santalinus Stem Extract is a valuable botanical ingredient, providing substantial antioxidant and anti-inflammatory benefits with good skin compatibility, making it suitable for addressing a variety of targeted skincare concerns.

Related

Similar Ingredients

Finding similar ingredients…