Science
Mechanism of Action
This extract functions through several key pathways: potent antioxidant activity from its richness in bioactive molecules such as polyphenols, flavonoids, and vitamins A/C, which neutralize free radicals and oxidative stress. Its anti-inflammatory action suppresses pro-inflammatory mediators including IL-1β, IL-6, TNF-α, COX-2, and iNOS, often by inhibiting NF-κB and STAT3 signaling pathways. Furthermore, its vitamin C content promotes collagen production for improved elasticity, while vitamin A aids in diminishing the appearance of sagging, wrinkles, and hyperpigmentation, collectively enhancing epidermal differentiation.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro analysis showed efficient suppression of IL-1β, TNF-α, and IL-6 mRNA expression, and inhibition of COX-2 and iNOS protein expression at 300 µg/mL (0.03%), indicating strong anti-inflammatory potential.
- 02 Another in vitro study demonstrated significant antioxidant activity (7.27% using the FTC method) with an ethyl acetate extract at 0.05%.
- 03 A 5-week oral administration study of a winged bean seed extract in a human skin lichenification model inhibited wrinkle formation and modulated genes linked to epidermal differentiation and inflammation, suggesting systemic benefits relevant to skin health.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Optimal pH range for cosmetic stability is not documented in available literature. Information on pH largely pertains to protein extraction from seeds (optimal around pH 12, minimum extractability at pH 4) or soil conditions for plant growth (cannot withstand pH < 5.5), which are not directly applicable to the root extract's stability in a skincare formulation.
Safety
Safety Profile
While winged bean (Psophocarpus tetragonolobus) and its various parts are generally considered safe for human consumption and have a history of use in traditional medicine and cuisine, its safety specifically for topical cosmetic applications has not been formally assessed by regulatory bodies like CIR or SCCS.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Psophocarpus Tetragonolobus Root Extract is a valuable botanical ingredient offering significant antioxidant and anti-inflammatory benefits, with potential to improve skin elasticity and reduce signs of aging based on in vitro and oral studies.
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References
Sources