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Moumoujus

PSIDIUM GUAJAVA LEAF OIL.

Valuable CAS 91770-12-6 (generic) / FRAGRANCE

Psidium Guajava Leaf Oil is a multifaceted botanical extract recognized for its comprehensive skincare benefits. It provides potent antioxidant protection, exhibits significant antimicrobial action particularly against acne-causing bacteria, and offers anti-inflammatory properties. Beyond targeted treatments, it functions as a skin conditioner, moisturizer, and astringent, supporting overall dermal health and appearance.

Summary

Astringent Skin conditioning Antioxidant Antimicrobial Anti-inflammatory Moisturizer

Science

Mechanism of Action

This botanical oil exerts its effects through multiple pathways. Its antioxidant capacity stems from the neutralization of free radicals, which helps preserve vital skin protein structures and mitigate signs of premature aging, such as fine lines. Bioactive compounds including flavonoids, tannins, saponins, and triterpenoids contribute to its anti-inflammatory actions. Moreover, it demonstrates antimicrobial efficacy by inhibiting microbial growth, specifically targeting strains like Cutibacterium granulosum and Staphylococcus species associated with acne. The oil also supports skin hydration by enhancing moisture retention and helps maintain elasticity, while refining pore appearance due to its astringent qualities. It can promote a more uniform skin tone by assisting in cellular turnover and modulating melanin production through tyrosinase inhibition.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrated Minimum Inhibitory Concentrations (MICs) against oral pathogens Candida albicans and Streptococcus mutans, exhibiting antimicrobial activity at 0.05-0.1%.
  2. 02 Achieved Minimum Inhibitory Concentration (MIC) of 3.125 µg/ml and Minimum Bacterial Concentration (MBC) of 6.25 µg/ml against Cutibacterium granulosum, indicating significant antimicrobial activity relevant for acne treatment.
  3. 03 Exhibited potent antioxidant capacity, measured by a half maximal inhibitory concentration (IC50) of 32.7 ± 0.3 mg/ml using the DPPH method.

Transparency

Dusting Analysis

Not commonly dusted

The ingredient's multi-functional profile is substantiated by specific in vitro research demonstrating antimicrobial and antioxidant efficacy, suggesting genuine biological activity rather than superficial marketing claims.

The Formula

Formulation

Solubility
Oil
Optimal pH 4 – 10
0 7 14

Stability

The essential oil typically presents low physicochemical stability and limited solubility in water. However, stability can be significantly enhanced for over 90 days within a pH range of 4 to 10 when encapsulated, for instance, in nanoparticles or hydroxypropyl-beta-cyclodextrin. Utilizing microemulsions, particularly water-in-oil systems, can also improve skin penetration.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

While specific regulatory reviews (CIR, SCCS, FDA) for Psidium Guajava Leaf Oil are not explicitly available, manufacturers generally certify it as suitable for cosmetic application and not included in lists of prohibited substances. For Psidium Guajava Leaf Extract, INCI Beauty indicates 'No penalty' across all safety categories, suggesting a generally favorable profile for related forms.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Psidium Guajava Leaf Oil offers a valuable multi-functional profile with demonstrated antimicrobial and antioxidant benefits, making it a promising ingredient for diverse skincare formulations, particularly those targeting acne and aging concerns.

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