Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

PSICOSE.

Valuable CAS 23140-52-5 / HUMECTANT, SKIN CONDITIONING

Psicose, also known as D-Allulose, is a natural rare sugar with demonstrated potential in precision skincare. It primarily targets hyperpigmentation by inhibiting melanin synthesis and offers an auxiliary antioxidant benefit through radical scavenging.

Summary

Antioxidant Brightening Hyperpigmentation treatment

Science

Mechanism of Action

D-Allulose (Psicose) acts on hyperpigmented skin by actively reducing melanin deposition, achieving this through the direct inhibition of melanin synthesis pathways. Furthermore, it exerts an antioxidant effect by neutralizing reactive oxygen radicals, which can contribute to skin damage and uneven tone.

Research

Clinical Evidence

Medium confidence
Effective range 0.2–60%
Optimal

N/A

Key findings

  1. 01 WO2020122667A1
  2. 02 EP3895687A1

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Psicose demonstrates robust stability across various conditions, tolerating temperatures up to 180°C and resisting degradation in both acidic and alkaline environments.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
60%
Sensitization risk Unknown

The FDA has recognized Allulose as Generally Recognized As Safe (GRAS) for use as a sugar substitute in various food categories within the US. It is approved in Japan, South Korea, Singapore, and Mexico, but is not currently permitted for sale in Europe. For topical cosmetic compositions, concentrations up to 60% by weight are considered effective for reducing pigmentation.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Psicose presents a valuable ingredient for targeting hyperpigmentation through melanin synthesis inhibition and offering antioxidant protection, with favorable stability characteristics, though further specific cosmetic safety reviews are pending.

Related

Similar Ingredients

Finding similar ingredients…