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Moumoujus

PRUNUS YEDOENSIS LEAF EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Prunus Yedoensis Leaf Extract is a multi-functional botanical ingredient recognized for its potent anti-inflammatory and antioxidant capabilities. It actively soothes skin, mitigates environmental stressors, and promotes a brighter, more refined complexion. This extract leverages a rich profile of bioactive compounds to deliver comprehensive skin benefits.

Summary

Antioxidant Skin-soothing Skin brightening Skin conditioning

Science

Mechanism of Action

This extract derives its dermatological efficacy from a rich composition of bioactive compounds, including phenolic acids, flavonoids, and tannins. It functions as a potent antioxidant by neutralizing free radicals and significantly reducing oxidative stress within skin cells. Its anti-inflammatory action is achieved by inhibiting the production of nitric oxide and the release of histamine, thereby calming irritated skin. Additionally, the extract contributes to anti-aging effects by attenuating UVB-induced DNA damage and supports skin conditioning by improving texture and inhibiting melanin production for a brightening effect.

Research

Clinical Evidence

High confidence
Effective range 0.338–3%
Optimal

2%

Key findings

  1. 01 Demonstrated significant anti-inflammatory effect by reducing nitric oxide (NO) production by 31.83% in LPS-treated RAW 264.7 cells in an in vitro model.
  2. 02 In a 9-day in vivo human study, a cream formulated with this extract significantly lowered visual irritation scores and erythema values in an SLS irritant patch test, confirming anti-inflammatory and soothing properties.
  3. 03 Exhibited dose-dependent antioxidant effects in UVB-irradiated HaCaT cells, reducing reactive oxygen species (ROS) and malondialdehyde (MDA) levels while boosting superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities.
  4. 04 Successfully attenuated UVB-induced DNA damage in HaCaT cells by decreasing the formation of cyclobutane pyrimidine dimers (CPDs) and 8-hydroxy-20-deoxyguanosine (8-OHdG).
  5. 05 Showed anti-inflammatory effects, including inhibition of histamine release and contact dermatitis, alongside whitening effects through melanin production inhibition in mouse B16 melanoma cells. Also improved skin roughness.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The phenolic and tannin compounds within the extract are susceptible to thermal degradation, with higher temperatures leading to a more significant decline in antioxidant activity. Optimal preservation of phenolic content and antioxidant properties is achieved at lower storage temperatures, such as 4 ± 2 °C. Elevated pH levels can accelerate the degradation of certain anthocyanins, suggesting better stability at acidic pH levels for some components.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Although not formally reviewed by CIR or SCCS, this ingredient is permitted for use as a quasi-drug in Japan. Dermal safety is supported by patch test results on a related Prunus species extract in a cream formulation, which revealed no signs of irritation.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Prunus Yedoensis Leaf Extract is a valuable active, demonstrating robust clinical efficacy in soothing, protecting, and brightening the skin across various concentrations.

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