Science
Mechanism of Action
This extract is rich in natural bioactive compounds, including phenolic acids, flavonoids, and tannins, which collectively contribute to its diverse skin benefits. It exerts significant antioxidant activity by neutralizing free radicals and reducing oxidative stress, effectively mitigating signs of aging caused by environmental exposure. Its anti-inflammatory action is demonstrated through a notable reduction in nitric oxide (NO) production and the inhibition of key inflammatory mediators. Furthermore, it acts as a skin conditioning agent, supporting improved texture and moisture balance, and has been associated with anti-aging effects such as improved elasticity and reduced wrinkle appearance, alongside potential brightening properties via tyrosinase inhibition.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 Reduced nitric oxide production by 31.83% in lipopolysaccharide (LPS)-treated RAW 264.7 cells, demonstrating significant anti-inflammatory efficacy (in vitro).
- 02 In a cream formulation, reduced visual irritation scores and erythema values during a 9-day sodium lauryl sulphate (SLS) irritant patch test on human volunteers (in vivo).
- 03 Dose-dependently decreased reactive oxygen species (ROS) and malondialdehyde (MDA) levels, while increasing the activity of antioxidant enzymes (SOD, GPx) in UVB-irradiated human keratinocytes (HaCaT cells), showcasing strong antioxidant and protective effects against oxidative stress (in vitro).
- 04 Attenuated UVB-induced DNA damage in HaCaT cells by reducing the formation of cyclobutane pyrimidine dimers and 8-hydroxy-20-deoxyguanosine (in vitro).
- 05 Improved rough skin texture and reduced scaliness on SDS-damaged skin, along with positive effects on noticeable pores, increased skin elasticity, and inhibition of bFGF production.
Transparency
Dusting Analysis
Clinical studies demonstrate efficacy across a range of concentrations, with antioxidant benefits observed as low as 0.5% and anti-inflammatory and skin conditioning effects seen at 2-3%. Formulations utilizing concentrations below 0.5% may not deliver the full spectrum of the ingredient's demonstrated benefits.
The Formula
Formulation
Stability
The active components of Prunus Yedoensis Branch/Leaf Extract are typically prepared using aqueous ethanol, suggesting water solubility. While no specific optimal pH range is defined for stability in cosmetic formulations, some studies indicate mild acidic conditions (e.g., pH 4.9) may support nanoparticle stability when synthesized with the extract.
Safety
Safety Profile
Generally regarded as non-irritating, with clinical studies supporting good anti-inflammatory effects up to 3% in topical formulations. A specific commercial variant (SAKURA Extract B) is permitted as a quasi-drug in Japan, reinforcing its safety profile for cosmetic use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A versatile and well-tolerated ingredient that provides significant anti-inflammatory, antioxidant, and skin conditioning benefits across various skin types, supported by robust in-vitro and in-vivo data at concentrations from 0.5% to 3%.
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