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Moumoujus

PRUNUS YEDOENSIS BARK EXTRACT.

Valuable / HUMECTANT, SKIN PROTECTING

Prunus Yedoensis Bark Extract is a multi-functional botanical ingredient engineered to significantly boost endogenous hyaluronic acid production and fortify the epidermal barrier. Its robust anti-inflammatory profile further positions it as a key component for calming sensitive or reactive skin and promoting overall skin resilience.

Summary

Antioxidant Skin-soothing Brightening Moisturizer/humectant

Science

Mechanism of Action

This extract operates by upregulating hyaluronic acid synthase-2 (HAS2) levels, thereby enhancing the skin's intrinsic hyaluronic acid synthesis and strengthening the epidermal barrier. Its anti-inflammatory action is mediated through the suppression of key inflammatory cytokines like TNF-α and IL-6, alongside the modulation of NF-κB and MAPK signaling pathways. Additionally, it influences tissue proliferation and inflammatory responses to support wound healing processes.

Research

Clinical Evidence

Medium confidence
Effective range 0.01–0.02%
Optimal

N/A

Key findings

  1. 01 Demonstrated a significant upregulation of hyaluronic acid (HA) expression and hyaluronic acid synthase-2 (HAS2) levels in cultured HaCaT keratinocytes, contributing to enhanced epidermal barrier function.
  2. 02 Reduced the expression of vascular cell adhesion molecules (VCAM-1, ICAM-1, E-selectin) in TNF-α activated human umbilical vein endothelial cells (HUVECs) at concentrations of 100 to 200 μg/mL (0.01-0.02%).
  3. 03 Showed a suppressive effect on inflammatory and macrophage gene expression, including tumor necrosis factor-α and interleukin-6, in adipose tissue of diet-induced obese mice via oral administration.
  4. 04 Accelerated scald wound healing and increased wound contraction rates in rat models, with observed effects from 12 days post-scald.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Specific optimal pH for stability is not yet precisely defined. However, the extract's preparation using aqueous and ethanolic solutions suggests excellent water solubility and inherent stability across typical cosmetic formulation pH ranges.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Formal safety assessments by major regulatory bodies such as CIR, SCCS, or FDA specifically for Prunus Yedoensis Bark Extract are currently unavailable. Related entries for Prunus Yedoensis (branch/leaf extract) indicate dermal toxicity as 'not determined'.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Prunus Yedoensis Bark Extract is a valuable ingredient for its demonstrated ability to enhance skin hydration and barrier integrity via hyaluronic acid synthesis, coupled with notable soothing and anti-inflammatory properties.

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