Science
Mechanism of Action
Prunus Serrulata Flower Extract exerts its effects through a rich composition of flavonoids, polyphenols, phenolic acids, anthocyanins, and vitamins (A, B, E). These compounds function as potent antioxidants, neutralizing reactive oxygen species (ROS) and mitigating oxidative stress. Its anti-inflammatory action is evidenced by its ability to reduce nitric oxide (NO) production and calm irritation. Furthermore, it inhibits tyrosinase, an enzyme crucial for melanin synthesis, leading to visible skin brightening. The extract also contributes to skin hydration, supports natural cell turnover, and strengthens the skin's protective barrier. Its anti-aging properties stem from the inhibition of glycation, preserving collagen and elastin integrity, and protecting keratinocytes from UVB-induced damage and apoptosis.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Protected HaCaT cells from UVB-induced oxidative stress and apoptosis, decreased reactive oxygen species (ROS) and malondialdehyde levels, and increased superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, indicating significant photoprotective benefits.
- 02 Reduced nitric oxide (NO) production by 31.83% in lipopolysaccharide (LPS)-treated RAW 264.7 cells, demonstrating potent anti-inflammatory effects.
- 03 Significantly reduced visual irritation scores and erythema values in an SLS irritant patch test on human volunteers, confirming anti-inflammatory efficacy in vivo.
- 04 When combined with 200 mg Rosa roxburghii Tratt fruit extract, an oral supplement improved facial and body skin aging phenotypes, including increased skin moisture (up to 28.07%), reduced skin roughness (26.15%), decreased forehead wrinkles (37.07%), crow's feet (32.78%), and nasolabial folds (16.76%), alongside improved skin brightness and reduced melanin levels.
Transparency
Dusting Analysis
This ingredient is utilized for its functional benefits and is typically incorporated at effective concentrations, rather than being used at sub-efficacious levels for marketing purposes.
The Formula
Formulation
Stability
The extract demonstrates good physical stability in formulations under ambient and thermal cycling conditions. To preserve the bioactivity of its anthocyanin content, it is advisable to formulate at acidic pH levels. Storage in a cool, dry place away from direct sunlight is recommended.
Safety
Safety Profile
Generally considered safe for topical application, though individuals with pre-existing allergies or highly sensitive skin should exercise caution due to the potential for individual reactions such as redness or itching. The Cosmetic Ingredient Review (CIR) has not yet reviewed this ingredient. Regulatory bodies like the European Cosmetics Regulation permit its use in cosmetic products. The U.S. FDA has issued a 'Generally Recognized As Safe (GRAS)' notice for a related Prunus serrulata flower extract as a flavoring agent for ingestion, which is distinct from its topical cosmetic application. EWG Skin Deep rates this ingredient as 'LOW' hazard for Cancer, Allergies & Immunotoxicity, and Developmental and Reproductive Toxicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Prunus Serrulata Flower Extract is a valuable ingredient, demonstrating robust antioxidant and anti-inflammatory properties, with promising clinical evidence supporting its efficacy in skin brightening, hydration, and overall anti-aging strategies.
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