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Moumoujus

PRUNUS CERASUS LEAF EXTRACT.

Valuable CAS 89997-53-5 / ANTIOXIDANT

Prunus Cerasus Leaf Extract is a botanical active, rich in potent phenolic and flavonoid compounds. It functions as a powerful antioxidant, mitigating oxidative stress, and provides significant anti-inflammatory benefits to soothe and protect the skin. Additionally, it offers brightening and conditioning properties, contributing to a more even-toned and supple complexion.

Summary

antioxidant anti-inflammatory skin brightening skin conditioning moisturizing keratolytic photoprotective

Science

Mechanism of Action

This extract operates through a multifaceted approach, primarily due to its abundance of phenolic and flavonoid compounds, including rutin. It potently neutralizes free radicals, thereby reducing oxidative stress and inhibiting lipid peroxidation, which protects cellular integrity against environmental damage. Its anti-inflammatory action involves modulating key mediators such as nitric oxide, interleukin-6, and tumor necrosis factor-alpha, effectively calming irritation and redness. Furthermore, it exhibits anti-tyrosinase activity to address hyperpigmentation and supports skin conditioning for improved texture and hydration. The extract also contributes to UVB photoprotection, potentially enhancing a product's SPF.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A cream formulation containing a closely related Prunus leaf extract (Prunus cerasifera) demonstrated dermal safety, showing no signs of irritation in a semi-open patch test on 26 healthy volunteers. The formulation maintained physical stability and retained over 74.5% antioxidant activity under thermal cycling conditions, also exhibiting antioxidant, anti-lipid peroxidation, anti-tyrosinase, and anti-inflammatory properties.
  2. 02 Sour cherry aqueous leaf extract (Prunus cerasus) inhibited nitrite production in a dose-dependent manner in RAW 264.7 cells and macrophages, indicating anti-inflammatory potential.
  3. 03 Tart cherry (Prunus cerasus) extract exhibited dose-dependent repression of ARE-driven transcriptional activity and significant intracellular ROS scavenging activity in human hepatocytes.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Ethanolic extracts of Prunus leaves are recognized for their stability. Formulations containing related Prunus extracts have shown good physical stability under ambient conditions and sustained over 74.5% antioxidant activity after thermal cycling tests. While not specific to this extract, related fruit extracts in body wash formulations were adjusted to pH 5.5 for optimal performance.

Conflicts

  • The inclusion of cherry and sweet cherry fruit extracts in body wash formulations has been observed to result in a decrease in viscosity. This potential rheological effect should be considered, particularly for similar product types or when formulating with other Prunus extracts.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While not officially reviewed by CIR, SCCS, or FDA, a cream formulation containing a closely related Prunus leaf extract demonstrated dermal safety with no signs of irritation in a human patch test on 26 healthy volunteers. The ingredient is also rated 'Irritant Free' by SkinSAFE, suggesting a low risk of skin adverse reactions.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Prunus Cerasus Leaf Extract is a valuable, multifunctional botanical offering potent antioxidant, anti-inflammatory, and brightening properties, making it suitable for a wide range of precision skincare applications across all skin types.

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