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Moumoujus

PRUNUS CERASUS LEAF CELL EXTRACT.

Valuable CAS 89997-53-5 / ANTIOXIDANT, SKIN CONDITIONING

PRUNUS CERASUS LEAF CELL EXTRACT is a potent botanical ingredient derived from sour cherry leaves, recognized for its robust antioxidant and anti-inflammatory capabilities. Rich in beneficial polyphenols and anthocyanins, it actively works to protect and soothe the skin, promoting a healthier, more resilient complexion. It also functions effectively as a skin conditioning agent.

Summary

Antioxidant Anti-inflammatory Skin conditioning

Science

Mechanism of Action

This extract primarily operates as an antioxidant and anti-inflammatory agent. It robustly scavenges intracellular Reactive Oxygen Species (ROS), protecting cells from oxidative stress. Its efficacy stems from its high content of polyphenols and anthocyanins. Mechanistically, it reduces H2O2 or LPS-induced ROS in human skin keratinocytes, concurrently upregulating the expression of antioxidant enzymes such as Catalase (CAT) and Superoxide Dismutase 1 (SOD1). Concurrently, it downregulates the pro-oxidant regulator Nitric Oxide Synthase 2 (NOS2) and inhibits nitrite production, indicative of its significant anti-inflammatory actions. Beyond these protective roles, it functions to condition the skin, supporting overall dermal health.

Research

Clinical Evidence

High confidence
Effective range 58.25–195%
Optimal

N/A

Key findings

  1. 01 Sour cherry aqueous leaf extract demonstrated anti-inflammatory potential by inhibiting nitrite production with an IC50 of 58.25 ± 0.36 µg/mL.
  2. 02 Prunus cerasus extract exhibited potent intracellular ROS scavenging activity in HepG2 cells at an EC50 of 72.02 µg/mL.
  3. 03 The extract showed dose-dependent repression of Antioxidant Response Element (ARE) activity, achieving up to 70% inhibition at 98 µg/mL within a range of 0.77 to 195 µg/mL.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 2.8 – 5
0 7 14

Stability

Key active compounds, including anthocyanins and polyphenols, exhibit enhanced stability within an acidic pH range. Formulations should ideally maintain a pH between 2.8 and 5.0 to preserve the extract's integrity and efficacy, consistent with reported optimal extraction and stability conditions.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While specific CIR, SCCS, or FDA safety assessments for 'PRUNUS CERASUS LEAF CELL EXTRACT' are not yet available, related research indicates a favorable safety profile. Sour cherry aqueous leaf extract demonstrated no cytotoxic effects on RAW 264.7 cells and macrophages. Additionally, tart cherry pit extracts at concentrations up to 400 nM showed no adverse effects on the viability of human keratinocyte (HaCaT) or fibroblast (NIH3T3) cells. General cherry extracts in body wash formulations have shown low irritancy in epidermal patch tests, suggesting a generally well-tolerated ingredient.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

PRUNUS CERASUS LEAF CELL EXTRACT is a valuable ingredient, delivering robust antioxidant and anti-inflammatory benefits with good skin compatibility and low irritancy, making it suitable for a wide range of precision skincare applications.

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