Science
Mechanism of Action
This extract's efficacy stems from its abundant content of bioactive compounds, including phenolic acids, flavonoids (like rutin), and tannins. It functions as a potent antioxidant by effectively neutralizing free radicals, thereby minimizing oxidative stress to protect skin from environmental damage and signs of aging. Its anti-inflammatory capabilities are evident through its ability to modulate inflammatory mediators, specifically inhibiting nitric oxide, interleukin-6, and tumor necrosis factor-alpha, which helps to calm skin irritation and reduce visible redness. The extract also supports skin conditioning, enhancing texture and aiding in moisture retention. Furthermore, it may contribute to a brighter complexion by inhibiting tyrosinase, addressing hyperpigmentation, and has been observed to improve skin elasticity and reduce the appearance of enlarged pores by inhibiting bFGF production.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 An in vitro study demonstrated that 2% Prunus yedoensis extract significantly reduced nitric oxide production by 31.83% in LPS-treated RAW 264.7 macrophage cells, indicating a potent anti-inflammatory effect.
- 02 A 9-day in vivo human study involving 40 volunteers showed that a cream with 3% Prunus yedoensis extract effectively lowered visual irritation scores and erythema values in an SLS irritant patch test compared to a placebo, confirming its anti-inflammatory action.
- 03 In vitro research on HaCaT cells revealed that concentrations from 0.5% to 2.0% protected against UVB-induced oxidative stress and apoptosis in a dose-dependent manner. This was evidenced by decreased reactive oxygen species and malondialdehyde levels, alongside increased superoxide dismutase and glutathione peroxidase activities.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
For optimal stability, this extract is recommended for use within a neutral pH range of 5.0 to 8.0. Formulation outside this range, particularly at alkaline pH, may compromise stability, potentially leading to color changes and degradation of key bioactive compounds like anthocyanins (for related Prunus species).
Safety
Safety Profile
While a dedicated safety assessment from CIR, SCCS, or FDA is not currently available for Prunus Campanulata/Yedoensis Leaf Extract, it is widely regarded as non-irritating and noncomedogenic. Clinical data includes an in vivo study where a 3% Prunus yedoensis extract cream demonstrated significant soothing effects on irritated skin. Dermal safety was also observed in patch tests for a related Prunus leaf extract (P. cerasifera). However, individuals with known sensitivities to plant extracts should be aware of the potential for allergic reactions.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Prunus Campanulata/Yedoensis Leaf Extract is a valuable botanical ingredient, offering significant antioxidant, anti-inflammatory, and conditioning benefits suitable for a wide range of skin types and formulations.
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