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Moumoujus

PROPYLENE GLYCOL CAPRYLATE.

Valuable CAS 31565-12-5 / 68332-79-6 / SKIN CONDITIONING, SURFACTANT - CLEANSING

Propylene Glycol Caprylate is a versatile monoester primarily recognized for its advanced ability to enhance the dermal penetration of active cosmetic ingredients. Beyond boosting ingredient efficacy, it acts as an emollient and humectant, contributing to skin hydration and overall product stability.

Summary

Penetration Enhancer Emollient Humectant Skin-conditioning agent Solubilizer Emulsifying Viscosity controlling Antimicrobial (mild)

Science

Mechanism of Action

This ingredient functions by increasing the molecular mobility within the oil phase of topical formulations, while simultaneously reducing molecular interactions among oil components. This dual action facilitates deeper and more efficient skin penetration of active ingredients. Additionally, it draws moisture from the atmosphere to hydrate the skin, acts as a solubilizer for diverse ingredient types, and serves as a co-emulsifier to improve emulsion texture and stability. It also offers mild antimicrobial properties.

Research

Clinical Evidence

High confidence
Effective range 5–5%
Optimal

5%

Key findings

  1. 01 At a 5% concentration, studies have shown a significant increase in the dermal penetration of diclofenac and 5-fluorouracil through rat abdominal skin.
  2. 02 In hydrotropic formulations, a 5% concentration increased the enhancement factor for sodium salicylate from 3.85 to 1250, and for sodium benzoate from 2.74 to 1115. It also raised the enhancement factor from 3.15 to 13 in a mixed micelle formulation.
  3. 03 Research indicates a notable enhancement of drug skin retention, specifically for roflumilast when incorporated into a cream formulation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Propylene Glycol Caprylate exhibits robust stability across a wide range of pH and temperature conditions. Formulations containing this ingredient have demonstrated stability in simulated physiological environments at pH 6.8 and pH 7.5.

Synergies

  • Enhances the bioavailability and efficacy of various active cosmetic and pharmaceutical ingredients.
  • Supports stable emulsion formation and refined product textures as a co-emulsifier.
  • Facilitates incorporation of diverse oil and water-based compounds as a solubilizer.

Conflicts

  • Strong oxidizing agents
  • Prolonged heat

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Propylene Glycol Caprylate is safe for use in cosmetics when formulated to be non-irritating.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

A valuable multi-functional ingredient, Propylene Glycol Caprylate significantly amplifies the efficacy of active compounds by enhancing their skin penetration, while simultaneously providing hydration and improving the stability and texture of formulations.

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