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PROPANOYLRESORCINOL.

Valuable CAS 5792-36-9 / ANTIOXIDANT

While the name 'PROPANOYLRESORCINOL' is not a recognized INCI designation, the provided data exclusively describes Phenylethyl Resorcinol, commonly known as SymWhite 377. This highly effective resorcinol derivative is a precision ingredient formulated to visibly reduce hyperpigmentation, even skin tone, and deliver antioxidant protection, enhancing overall skin radiance.

Summary

Antioxidant Skin brightening Melanin synthesis inhibition

Science

Mechanism of Action

Phenylethyl Resorcinol operates primarily as an exceptionally potent inhibitor of tyrosinase, the key enzyme in melanin synthesis, significantly curbing dark spot formation. Its inhibitory effect is noted to be 22 times greater than that of kojic acid. Additionally, it provides robust antioxidant defense against free radical damage and actively intervenes in melanogenesis by initiating the degradation of the MITF protein, which regulates tyrosinase expression.

Research

Clinical Evidence

High confidence
Effective range 0.1–0.5%
Optimal

0.5%

Key findings

  1. 01 At 0.5% concentration, it demonstrated superior skin brightening efficacy compared to 1.0% kojic acid in a clinical study involving Asian subjects.
  2. 02 Studies have shown significant reductions in hyperpigmentation and marked improvements in skin lightness and evenness after 12 weeks of consistent use.
  3. 03 A serum containing SymWhite 377 effectively diminished facial hyperpigmentation in 28 subjects without inducing irritation or adverse effects.
  4. 04 In a study of 80 participants, a formulation with SymWhite 377 alongside other actives led to 57% moderate improvement in skin brightening, with another study reporting a 43% reduction in uneven skin tone among 20 women.

Transparency

Dusting Analysis

Not commonly dusted

No specific information regarding exaggerated marketing claims or 'dusting' thresholds for Phenylethyl Resorcinol (SymWhite 377) was identified within the provided research data.

The Formula

Formulation

Solubility
Oil
Optimal pH 4 – 6
0 7 14

Stability

Phenylethyl Resorcinol exhibits strong stability within a pH range of 4.0 to 6.0. While it has low water solubility (0.159 g/L to 3.85 g/L), it dissolves effectively in oils and glycols, crucial for stable emulsion formulations.

Conflicts

  • Copper
  • Carbomer
  • Carbopol
  • Amino Acids (potential for yellowing/separation)
  • Ureas (potential for yellowing/separation)
  • Proteins (potential for yellowing/separation)
  • Some fragrances (potential for yellowing/stratification)

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
0.5%
Sensitization risk Low

All safety evaluations pertain to Phenylethyl Resorcinol (SymWhite 377), an ingredient recognized for its high purity and safety profile within the recommended concentration range of 0.1% to 0.5%. While generally non-irritating and non-sensitizing, documented instances of irritation and contact dermatitis have occurred at concentrations of 1% to 2%. Isolated cases of allergic reactions, such as redness or itching, have also been reported. The specified ingredient 'PROPANOYLRESORCINOL' is not an established INCI name, and all scientific data referenced herein applies solely to Phenylethyl Resorcinol.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Phenylethyl Resorcinol (SymWhite 377) is a highly valuable active ingredient for precision skincare, demonstrating potent efficacy in reducing hyperpigmentation and improving skin tone and brightness, provided it is formulated and utilized within its established safe and effective concentration range.

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