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PROPANEDIOL DIPELARGONATE.

Valuable CAS 28267-33-6 / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Propanediol Dipelargonate is a multi-functional ester serving as a skin conditioning agent, emulsifier, and nonaqueous viscosity enhancer. It contributes to a softened and smoother skin texture, while also showing a capacity to boost the dermal absorption of other active ingredients.

Summary

Skin Conditioning Agent Emollient Occlusive Viscosity Increasing Agent (Nonaqueous) Surfactant (Emulsifying Agent) Penetration Enhancer

Science

Mechanism of Action

This ingredient functions primarily as a skin conditioning agent, providing emollient and occlusive properties that help soften and smooth the skin's surface. Additionally, it acts as an emulsifying surfactant, aiding in the stabilization of formulations, and can increase the viscosity of nonaqueous products. Notably, it has demonstrated the ability to enhance the skin penetration of certain chemicals, potentially improving the delivery of other beneficial compounds.

Research

Clinical Evidence

Medium confidence
Effective range 0.8–60%
Optimal

N/A

Key findings

  1. 01 Demonstrated enhancement of dermal penetration for thiocolchicoside when incorporated into an aqueous foam formulation.

Transparency

Dusting Analysis

Not commonly dusted

No data suggests 'dusting' behavior for Propanediol Dipelargonate at higher concentrations; rather, it has been used in formulations at levels up to 60% without reported issues.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

As a diester of propylene glycol and fatty acids, Propanediol Dipelargonate exhibits high lipophilicity, indicated by an XLogP3 of 7.5, ensuring its stability and solubility in oil-based systems.

Synergies

  • May enhance the dermal penetration of other active ingredients, potentially increasing their efficacy.

Conflicts

  • Formulators should exercise caution when combining with active ingredients whose established safety limits are based on low dermal absorption, as Propanediol Dipelargonate may increase their skin penetration.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
60%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has deemed Propylene Glycol Dipelargonate (an accepted synonym) safe for cosmetic use. The FDA permits similar propylene glycol mono- and diesters of fats and fatty acids as direct food additives, and its use is permissible in Europe under the Cosmetics Regulation of the European Union.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Propanediol Dipelargonate is a valuable multi-functional ingredient offering skin conditioning, emulsifying properties, and the notable benefit of enhancing the delivery of other actives, all within a strong safety profile.

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