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PPG-1-ISODECETH-4.

Valuable CAS - / CLEANSING, SURFACTANT - EMULSIFYING

PPG-1-ISODECETH-4 is a multifunctional polypropylene glycol derivative employed in skincare for its solvent and emulsifying properties. It effectively solubilizes challenging ingredients into aqueous solutions and stabilizes oil-in-water emulsions. This ingredient is designed to enhance formulation aesthetics and product stability.

Summary

Solubilizer Emulsifier Solvent Penetration Enhancer

Science

Mechanism of Action

This ingredient functions primarily as a solubilizer and solvent, enabling the dissolution of water-insoluble or sparingly soluble substances into homogeneous aqueous solutions. Its molecular structure features both lipophilic and hydrophilic components, allowing it to act as an emulsifier by reducing interfacial tension between immiscible phases like oil and water, thereby forming stable emulsions. Additionally, related propylene glycol compounds are known to enhance the dermal penetration of other molecules through interactions with stratum corneum lipids, which increases their mobility and disrupts their packing.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

PPG-1-ISODECETH-4, as a water-soluble and non-greasy polypropylene glycol derivative, is generally expected to exhibit good stability in cosmetic formulations. While a precise optimal pH range for this specific molecule is not available, related isodecyl alcohol ethoxylates demonstrate stable activity across a broad pH spectrum, from acidic to alkaline conditions, suggesting robust compatibility in diverse product environments.

Safety

Safety Profile

CIR Status
Safe with restrictions
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel concluded that alkyl PEG/PPG ethers, including PPG-1-ISODECETH-4, are safe for use in cosmetic products when formulated to be non-irritating. Due to its larger molecular size, it is considered less likely to penetrate the skin significantly or enter systemic circulation. However, formulators must consider the potential for residual impurities such as ethylene oxide, propylene oxide, and 1,4-dioxane, which were subjects of discussion in the CIR report. Although a related ingredient, PPG-2-ISODECETH-12, has been flagged for high contamination concerns by EWG, its overall irritation potential was deemed low, though a comprehensive weight of evidence for irritation was not assessed by CIR for that specific compound.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

PPG-1-ISODECETH-4 is a valuable functional ingredient for improving formulation stability and ingredient solubilization, with a CIR safety status of 'safe with restrictions' when formulated to be non-irritating.

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