Science
Mechanism of Action
This extract operates through several key pathways. For skin, it exhibits potent anti-inflammatory effects by inhibiting NF-κB, STAT1, and ERK activation, and reducing pro-inflammatory chemokine release. Its antioxidant capacity stems from a rich profile of phenolic acids, flavonoids, and triterpenoids. Crucially, it acts as an anti-aging agent by suppressing HYBID-mediated hyaluronan degradation and fostering the production of high-molecular-weight hyaluronan in fibroblasts, thereby enhancing skin elasticity and reducing wrinkle formation. Furthermore, it possesses antibacterial properties. In hair care, it functions as a fibroblast growth factor-5 (FGF-5) inhibitor, preventing hair follicles from prematurely transitioning from the anagen (growth) to the catagen (resting) phase, which prolongs the growth cycle and reduces shedding.
Research
Clinical Evidence
High confidence10%
Transparency
Dusting Analysis
No information provided to suggest common dusting practices for this ingredient.
The Formula
Formulation
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has not yet assessed Sanguisorba Officinalis Root Extract, and comprehensive oral, parenteral, and dermal toxicity data remain undetermined. However, preliminary evaluations suggest a low irritancy potential.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Poterium Sanguisorba Root Extract is a valuable active ingredient, demonstrating proven efficacy in both combating hair loss and delivering significant anti-aging, elasticity-boosting, and anti-inflammatory benefits for skin, with a favorable low irritancy profile.
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