POTENTILLA FRAGARIOIDES EXTRACT.

This extract operates by boosting skin hydration through increased Aquaporin-3 (AQP3) and hyaluronic acid (HA) synthesis, concurrently preventing HA degradation. It fortifies the skin barrier by elevating Filaggrin (FLG) and other key moisturizing factors (TGM-1, HAS-1, HAS-2). Its anti-inflammatory action involves reducing cytokines such as TSLP, IL-33, and IL-4, and inhibiting inflammatory mediators like nitric oxide, prostaglandin E2, tumor necrosis factor-α, and interleukin-6. Potentilla fragarioides also provides antioxidant protection by scavenging free radicals and mitigating UVB-induced damage, with compounds like quercetin and (+)-catechin contributing to these activities. Furthermore, certain Potentilla species have shown an ability to inhibit melanin production and secretion, suggesting a role in skin brightening.