Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

POTATO SH-POLYPEPTIDE-9.

Valuable / ANTIOXIDANT, HAIR CONDITIONING, SKIN PROTECTING

Potato SH-Polypeptide-9 is a synthetic, recombinant analog of human Vascular Endothelial Growth Factor A (VEGFA), designed to enhance dermal vitality. This sophisticated peptide primarily functions by stimulating angiogenesis, thereby boosting microcirculation and supporting overall cellular regeneration for improved skin health.

Summary

Cell-signaling support Microcirculation enhancement Fibroblast nutrient delivery Collagen production support Cellular proliferation promotion Wound healing aid Anti-aging Skin rejuvenation Elasticity improvement Moisturization support Cell vitalization

Science

Mechanism of Action

This advanced peptide operates by precisely binding to specific receptors on endothelial cells, initiating a cascade that promotes angiogenesis—the critical formation of new micro-blood vessels. This process significantly enhances microcirculation within the skin, ensuring a robust delivery of essential nutrients and oxygen to the dermal layers, which is crucial for optimal cellular function. Furthermore, SH-Polypeptide-9 stimulates fibroblast cells, fostering collagen production, cell growth, migration, and aiding in tissue repair. This comprehensive action leads to improved skin hydration, elasticity, and a visible reduction in the signs of aging.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Growth factors, including SH-Polypeptide-9, are susceptible to destabilization in acidic environments, which can compromise their efficacy. For maximal activity, it is recommended to apply acidic formulations first, allowing them to absorb fully before applying products containing this peptide. Research suggests that encapsulation techniques, such as double-layer encapsulation, can enhance both the stability and biological activity of this ingredient.

Conflicts

  • Acidic environments (potential destabilization)

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

While a specific safety assessment for SH-Polypeptide-9 by the Cosmetic Ingredient Review (CIR) Expert Panel indicates 'insufficient data', general categories of proteins and peptides have typically been deemed safe. The Environmental Working Group (EWG) identifies SH-Polypeptide-9 with 'LOW' concern for cancer, allergies & immunotoxicity, and developmental and reproductive toxicity. The European Commission's CosIng database lists 'BARLEY SH-POLYPEPTIDE-9' as a skin conditioning agent without major restrictions. However, due to its VEGFA-like activity, individuals with psoriasis should avoid products containing this ingredient, as it may exacerbate their condition. Use on sunburned skin or after high doses of UV radiation is also not recommended.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Potato SH-Polypeptide-9 is a valuable biomimetic peptide offering significant benefits for skin regeneration and vitality through its potent microcirculation and collagen-stimulating properties, despite the current absence of specific CIR safety data.

Related

Similar Ingredients

Finding similar ingredients…