Science
Mechanism of Action
This polypeptide actively stimulates the proliferation of fibroblasts, leading to increased synthesis of collagen and elastin for improved skin firmness and elasticity. Concurrently, it enhances keratinocyte growth, accelerating skin regeneration and wound repair. Its potent antioxidant properties help combat free radicals, mitigating cellular aging, blocking programmed cell death, and minimizing the appearance of fine lines and deep wrinkles. It also promotes vascularization, improving blood circulation and supporting hair cell proliferation for stronger hair. Effective penetration into deeper skin layers necessitates encapsulation within advanced carrier systems, such as liposomes or nanoliposomes, due to its substantial molecular size.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Randomized, multicenter, double-blind, and placebo-controlled clinical trials have demonstrated that topical administration of sh-Polypeptide-11 significantly accelerates wound healing and shortens recovery periods.
- 02 In-vitro studies confirm that Recombinant FGF-1 strongly stimulates both fibroblast and keratinocyte proliferation, key processes for effective skin regeneration and increased wound tensile strength and collagen deposition.
- 03 Studies indicate that aFGF improves wound healing in various clinical scenarios, including pressure sores, by promoting essential cellular activity.
Transparency
Dusting Analysis
Given its specific biological activity as a growth factor and its large molecular size requiring advanced carrier systems for efficacy, POTATO SH-POLYPEPTIDE-11 is not typically 'dusted'. Formulating with insufficient amounts or without proper delivery systems would render the ingredient ineffective.
The Formula
Formulation
Stability
Due to its large molecular size, sh-Polypeptide-11 cannot effectively penetrate the stratum corneum on its own. For optimal delivery and efficacy, it requires incorporation into sophisticated carrier systems such as liposomes or nanoliposomes.
Safety
Safety Profile
sh-Polypeptide-11 is a single-chain recombinant human peptide produced via fermentation in E. Coli. The Cosmetic Ingredient Review (CIR) has not yet assessed its safety. The Environmental Working Group (EWG) notes that products seeking EWG VERIFIED™ status require robust substantiation for the inclusion of this ingredient.
Your Skin
Skin Compatibility
Our Assessment
Verdict
POTATO SH-POLYPEPTIDE-11 is a valuable growth factor for advanced skincare, offering proven benefits in skin regeneration, anti-aging, and wound healing, provided it is formulated with appropriate delivery systems for optimal penetration.
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References
Sources