Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

POTATO SH-POLYPEPTIDE-1.

Valuable / SKIN PROTECTING

This advanced synthetic peptide, an analog of basic Fibroblast Growth Factor (bFGF), is engineered to stimulate critical cellular functions within the skin. It actively promotes the production of collagen, elastin, and hyaluronic acid, leading to enhanced skin elasticity, improved hydration, and a reduction in the appearance of wrinkles.

Summary

Cell-communicating ingredient Anti-aging Collagen booster Elastin booster Hyaluronic acid synthesis promoter Skin regeneration

Science

Mechanism of Action

Functioning as a potent mitogen, Potato sh-Polypeptide-1 accelerates the proliferation of dermal fibroblasts, the cells vital for synthesizing the skin's structural proteins, collagen and elastin, thereby firming skin and minimizing fine lines. It also synergistically interacts with EGF and IGF-1 to significantly upregulate hyaluronic acid production, resulting in smoother, more supple skin. Additionally, this peptide regulates molecular pathways to support new blood vessel formation, which enhances nutrient delivery to epidermal cells, and encourages melanocyte migration, offering potential benefits for re-pigmentation.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

As a relatively large recombinant molecule, its stability and dermal penetration are frequently enhanced through encapsulation within advanced delivery systems, such as liposomes or PLGA-coated nanoparticles. This ingredient has been successfully formulated with common cosmetic components including pentylene glycol, polysorbate, ascorbyl glucoside, disodium ethylenediaminetetraacetic acid, and niacinamide.

Synergies

  • Ascorbyl glucoside
  • Niacinamide

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Safety and toxicity studies on topical application of sh-Polypeptide-1 indicate no irritation, general toxicity, or significant adverse effects. However, due to its mimetic action of basic Fibroblast Growth Factor (bFGF), which has been linked to melanoma progression, its use in skincare applications should be approached with caution. This ingredient is not listed on EWG's Restricted or Unacceptable Lists.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Potato sh-Polypeptide-1 is a valuable anti-aging ingredient, lauded for its ability to stimulate collagen, elastin, and hyaluronic acid production, yet its bFGF-mimetic activity necessitates cautious application due to potential associations with melanoma progression.

Related

Similar Ingredients

Finding similar ingredients…