Science
Mechanism of Action
POTASSIUM NICOTINOYL ALANYL GLUTAMINE functions primarily as an antioxidant, neutralizing oxidative processes that can degrade other ingredients and impact skin health. Concurrently, it serves as a humectant, attracting and retaining moisture within the skin. The alanyl glutamine moiety, a stable form of glutamine, is crucial for skin vitality; it acts as a precursor for structural proteins such as collagen and elastin, promotes cellular hydration by upregulating aquaporin-3 (AQP-3) expression, and stimulates the production of vital glycosaminoglycans like hyaluronic acid. Topical application is suggested to improve its penetration into the stratum corneum, thus supporting collagen and hyaluronic acid synthesis and enhancing overall skin barrier function.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The alanyl glutamine component, a dipeptide, demonstrates maximum stability around pH 6.0. This dipeptide form is inherently more stable and soluble than free glutamine, showing greater resilience to thermal stress and extended storage periods. The broader stability for glutamine itself spans a pH range of 5.0 to 7.5.
Safety
Safety Profile
This specific ingredient has not undergone a dedicated review by the Cosmetic Ingredient Review (CIR) Expert Panel. However, the CIR Panel has assessed the safety of alpha-amino acids and amino acid alkyl amides, a broader chemical category that includes derivatives like this ingredient, concluding them safe for cosmetic applications when formulated to be non-irritating. No specific FDA cosmetic status was identified. Separately, the Joint FAO/WHO Expert Committee on Food Additives (JECFA) found no safety concerns for L-Alanyl-L-Glutamine, its dipeptide component, at current intake levels when used as a flavoring agent.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This ingredient shows promise as a multi-functional antioxidant and humectant, supporting skin health, but comprehensive safety data specific to this compound is currently limited.
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References
Sources