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POTASSIUM AZELOYL DIGLYCINATE.

Valuable CAS 477773-67-4 / SKIN CONDITIONING

A water-soluble derivative of azelaic acid, Potassium Azeloyl Diglycinate (PAD) is a versatile active ingredient for precision skincare. It effectively addresses concerns such as hyperpigmentation, acne, and redness, while simultaneously regulating sebum production and enhancing skin hydration and elasticity.

Summary

Skin brightening Sebum control Soothing Moisturizer/humectant Anti-acne

Science

Mechanism of Action

Potassium Azeloyl Diglycinate (PAD) operates through multiple biochemical pathways to improve skin health. It precisely inhibits tyrosinase, the enzyme responsible for melanin synthesis, thereby reducing hyperpigmentation and promoting a balanced skin tone. Its anti-inflammatory properties alleviate redness and irritation by downregulating pro-inflammatory cytokines, specifically interleukin-1α. PAD also modulates sebum production, effectively managing both excessive oiliness and dryness. Furthermore, it demonstrates anti-acne effects through antibacterial action and the inhibition of keratinization. The inclusion of glycine within its structure contributes to its moisturizing and hydrating capabilities, leading to improved skin elasticity and overall conditioning.

Research

Clinical Evidence

High confidence
Effective range 1–10%
Optimal

3%

Key findings

  1. 01 Proven effective in a serum formulation for individuals with sensitive skin, acne, rosacea, and compromised skin barrier health.
  2. 02 A cream formulation reduced erythema in rosacea patients within a 28-day period.
  3. 03 An aqueous solution reduced cutaneous lipids by 29.4-31.5%, increased skin moisture by 8.2-12.7%, and improved skin elasticity by 2.5% on oily and acne-affected skin over three weeks.
  4. 04 An anti-aging cream formulation demonstrated effective cell regeneration and enhanced skin moisture levels.

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
1%
Red flag below
0.5%

Potassium Azeloyl Diglycinate exhibits significant clinical benefits across a range of skin concerns at concentrations between 1% and 5%. While 1% is considered adequate for general effects, most studies demonstrating specific, quantifiable improvements utilize 3% or 5%. Formulations containing less than 1% are unlikely to provide the full spectrum of its beneficial actions, potentially indicating 'dusting' where insufficient active ingredient is present for meaningful efficacy.

The Formula

Formulation

Solubility
Water
Optimal pH 6 – 8
0 7 14

Stability

PAD is highly soluble in water, facilitating seamless integration into aqueous formulations such as clear gels, cleansers, toners, and serums. It is recommended to incorporate PAD during the final stage of formulation. For optimal stability, cosmetic temperatures should be maintained below 40°C, and the pH range of the final product should be between 6.0 and 8.0.

Conflicts

  • Zinc PCA
  • Strong acids (e.g., glycolic acid, salicylic acid, vitamin C) – may elevate irritation risk if not meticulously formulated to manage pH and concentration.
  • Other strong active ingredients, particularly retinoids or potent exfoliants – increased potential for skin irritation due to cumulative effect.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
5%
Sensitization risk Low

Potassium Azeloyl Diglycinate is considered non-toxic and safe for cosmetic use, demonstrating a low risk of irritation and minimal sensitization potential. Clinical assessments confirm its non-irritant and hypoallergenic profile. While generally gentle, mild and transient side effects such as redness or itching may occur during initial application, with excessive use, or when combined without careful consideration alongside strong exfoliants or retinoids.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Potassium Azeloyl Diglycinate is a valuable, multi-functional ingredient providing comprehensive benefits for skin brightening, anti-acne, sebum regulation, and soothing, with demonstrated high skin compatibility and a low irritation profile.

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