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Moumoujus

PORIA COCOS SCLEROTIUM EXTRACT.

Valuable CAS 168456-53-9 / ASTRINGENT

Derived from the Poria cocos mushroom, this potent extract is celebrated for its multifaceted benefits, including significant anti-aging, anti-inflammatory, and hydrating properties. It actively works to improve skin elasticity, reduce the appearance of fine lines, and promote a more even and radiant complexion by targeting key cellular processes.

Summary

Anti-inflammatory Antioxidant Moisturizer/Humectant Skin-soothing Astringent Anti-aging Skin-tightening Hydrating Immunomodulatory Skin tone evening

Science

Mechanism of Action

Poria Cocos Sclerotium Extract operates through several distinct pathways to enhance skin health. It demonstrates a proliferative effect on integrins, which helps to refine collagen structure, leading to observed skin tightening and a reduction in fine lines. As a powerful antioxidant, it actively neutralizes free radicals, thereby mitigating oxidative stress and its associated signs of skin aging. The extract exhibits strong anti-inflammatory properties by inhibiting phospholipase A2 (PLA2) and modulating immune responses, enhancing beneficial immune stimulators (IL-1β, IL-6, TNF-α at 0.4 mg/mL in vitro) while suppressing suppressors (TGF-β at 0.2 mg/mL in vitro), which helps to soothe irritation and reduce redness. Furthermore, it supports deep hydration, helps regulate sebum production, and strengthens the skin's natural barrier. Its components promote the synthesis of collagen and hyaluronic acid, crucial for maintaining skin volume and moisture, and contribute to fading dark spots and hyperpigmentation for improved skin texture and tone.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro, concentrations of 0.4 mg/mL increased the secretion of immune stimulators (IL-1β, IL-6, and TNF-α), while 0.2 mg/mL suppressed the secretion of an immune suppressor (TGF-β), indicating immunomodulatory potential.
  2. 02 Human dermal fibroblast studies showed the extract significantly protected against H2O2-induced cell death, reduced reactive oxygen species (ROS) accumulation, decreased metalloproteinases and inflammatory markers, and elevated TGF-β1 levels and antioxidant proteins, demonstrating potent anti-skin aging effects.
  3. 03 Lanostane triterpenoids extracted from Poria cocos ameliorated signs of aging skin and stimulated collagen and hyaluronic acid production in D-galactose-induced aging rats. Purified triterpenoids further increased collagen and hyaluronic acid levels in cultured human skin cells, underscoring its anti-aging and moisturizing capabilities.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

This extract is completely water-soluble, forming a transparent solution without sedimentation. While optimal pH for the extract's stability in cosmetic formulations isn't specified, optimal conditions for polysaccharide extraction are around pH 5, and polysaccharide hydrogels can maintain stability across a broad pH range (0.3-10.5). It can be formulated as a pale-yellow powder or a golden-yellow liquid.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No specific CIR, SCCS, or FDA regulatory review for cosmetic use was identified, yet the ingredient is generally considered safe for clinical application with no evident toxicity. The Environmental Working Group (EWG) rates Poria Cocos Sclerotium Extract with 'LOW' concerns across categories including cancer, allergies & immunotoxicity, and developmental/reproductive toxicity.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Poria Cocos Sclerotium Extract is a valuable ingredient, offering broad-spectrum benefits from anti-aging and hydration to soothing and skin tone improvement, making it suitable for a wide range of precision skincare applications.

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