Science
Mechanism of Action
This extract functions as a powerful antioxidant by leveraging its abundant phenolic compounds, including caffeic and p-coumaric acids, to effectively neutralize free radicals and diminish oxidative damage. Its anti-inflammatory action is demonstrated through the inhibition of key inflammatory cytokines such as IL-6, IL-10, and TNF-α, which visibly reduces redness and soothes irritation. Beyond these benefits, Populus Nigra Bud Extract supports overall skin vitality by regulating genes crucial for antioxidant defenses and cell renewal, thus promoting epidermal cell turnover and contributing to anti-aging effects. It also exhibits antimicrobial properties against common skin pathogens like *Staphylococcus aureus* and *Candida albicans*, aiding in skin purification and healing processes, and is traditionally valued for its soothing effects on conditions like dermatitis.
Research
Clinical Evidence
High confidence0.08%
Key findings
- 01 Exhibited strong cellular antioxidant properties, inhibiting up to 50% of radical production.
- 02 Reduced interleukin 6 (IL-6) production induced by interferon γ by 29%.
- 03 Significantly reduced interleukin 6 (IL-6) production induced by interferon γ by 66%.
- 04 Demonstrated significant anti-inflammatory effects by inhibiting the production of inflammatory cytokines (IL-6, IL-10, TNF-α) and blocking nuclear factor activation in vitro.
- 05 Regulated genes involved in antioxidant defenses, inflammatory response, and cell renewal in human dermal fibroblasts, indicating anti-aging potential.
Transparency
Dusting Analysis
No data available to suggest common dusting practices or specific thresholds for this ingredient.
The Formula
Formulation
Stability
Aqueous extracts and active compounds within Populus Nigra Bud Extract demonstrate stability in acidic mediums. Formulations (gels and emulgels) containing the extract maintain suitable stability and functionality within a pH range of 5.13 to 5.95 for topical application.
Conflicts
- Known aspirin allergy (due to salicylate content)
Safety
Safety Profile
Safety has been evaluated on normal human dermal fibroblasts at various in vitro concentrations. Individuals with a known aspirin allergy should exercise caution due to the presence of salicylates (e.g., salicin) within the extract, which may cause a reaction.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Populus Nigra Bud Extract is a valuable botanical ingredient, offering robust antioxidant, anti-inflammatory, and anti-aging benefits, making it highly suitable for precision skincare formulations targeting skin vitality and repair.
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References
Sources