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Moumoujus

PONGAMIA PINNATA LEAF EXTRACT.

Valuable / ANTIOXIDANT

Pongamia Pinnata Leaf Extract is a botanical active demonstrating potent antioxidant activity with an IC50 value of 1.051 in *in-vitro* analysis. It exhibits broad-spectrum antibacterial efficacy, notably against *Staphylococcus aureus* (up to 37.8 mm inhibition zone), and has shown anti-inflammatory properties in animal models, positioning it as a multifaceted ingredient for advanced skincare formulations.

Summary

antioxidant antibacterial anti-inflammatory antimicrobial soothing

Science

Mechanism of Action

This extract’s antioxidant effects are attributed to its diverse phytochemical profile. Its anti-inflammatory actions stem from these same constituents. Antimicrobial and antibacterial efficacy is linked to the presence of alkaloids, flavonoids, organic acids, saponins, and fatty acids. Furthermore, compounds like pongachromene and vitexin have been identified to interact with cancer-related targets (EGF, EGFR, ERBB2), suggesting a mechanism for its observed *in-vitro* cytotoxic effects, including cell cycle arrest and upregulation of the caspase 3 gene.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrated significant antioxidant activity *in vitro* with an IC50 value of 1.051.
  2. 02 Exhibited strong antibacterial activity in *in-vitro* tests. An ethanolic extract showed inhibition zones up to 38 mm against *Micrococcus luteus*, 37.8 mm against *Staphylococcus aureus*, and 33.6 mm against *Chromobacterium violaceum*. An ethyl acetate extract (1/2 w/v) displayed robust action against *Staphylococcus aureus* ATCC 25923 (16.33 mm sterile ring diameter) and Methicillin-Resistant *Staphylococcus aureus* (MRSA) (16.5 mm sterile ring diameter), comparable to Gentamicin sulfate (0.106 µg/ml for *S. aureus*, 0.089 µg/ml for MRSA).
  3. 03 A 70% ethanol fraction of leaves showed anti-inflammatory efficacy in rat models across severe, subacute, and constant inflammation representations.
  4. 04 Demonstrated cytotoxic effects on A431 skin cancer cells *in vitro* at a concentration of 89.59 μg/mL.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Currently, there are no specific CIR, SCCS, or FDA safety assessments available for Pongamia Pinnata Leaf Extract in cosmetic applications. While cosmetic ingredients in the EU are subject to regulation, no specific SCCS opinion has been issued for this ingredient.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Pongamia Pinnata Leaf Extract offers significant antioxidant, antibacterial, and anti-inflammatory benefits, making it a promising candidate for targeted skincare, though further safety assessments for cosmetic applications are warranted.

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