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Moumoujus

POMIFERIN.

Valuable CAS 572-03-2 / ANTIOXIDANT

Pomiferin is a precision flavonoid derived from the Osage orange (Maclura pomifera), lauded for its multifaceted effects on skin. It actively stimulates the synthesis of vital extracellular matrix proteins, powerfully combats oxidative stress, and significantly reduces inflammation, positioning it as a key ingredient for advanced skin rejuvenation.

Summary

Antioxidant Anti-inflammatory Extracellular Matrix (ECM) Stimulant Collagenase Inhibitor Elastase Inhibitor

Science

Mechanism of Action

Pomiferin functions as a potent stimulator of extracellular matrix proteins, demonstrably increasing the expression of collagen, elastin, and fibrillin. Its robust antioxidant capabilities are evident through its inhibition of lipid peroxidation and its ability to scavenge free radicals, reactive oxygen species (ROS), and other unstable molecules, rivaling the efficacy of well-known antioxidants like vitamins C, E, and BHT. Further, it upregulates key antioxidant genes, including ACLY, AQP3, and COX1, within human skin fibroblasts and keratinocytes. Pomiferin also exerts anti-inflammatory effects by suppressing the production of ROS, nitric oxide (NO), and various pro-inflammatory mediators such as IL-6, TNF-α, iNOS, and COX2, achieved through activation of the Akt/Nrf2 pathway and inhibition of the NF-κB pathway. Additionally, it provides protection against enzymatic degradation by inhibiting collagenase and elastase.

Research

Clinical Evidence

Medium confidence
Effective range 0.000005–0.1%
Optimal

N/A

Key findings

  1. 01 At concentrations ranging from 0.000005% to 0.0005% (0.05-5 ppm), Pomiferin significantly increased collagen and elastin expression in ex vivo hair follicle assays, demonstrating efficacy comparable to retinol.
  2. 02 A 0.1% concentration of Pomiferin exhibited strong antioxidant activity, comparable to or exceeding 0.02% BHT, in mitigating lipid autooxidation during storage of soybean and fish oil.
  3. 03 A Maclura pomifera 80% methanol extract containing Pomiferin, at 1 mg/mL, demonstrated significant collagenase inhibition, reaching 94.68% after 40 minutes in an in vitro assay, a performance comparable to 250 µg/mL EGCG.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Pomiferin powder is stable for 3 years when stored at -20°C; in solvent, it maintains stability for 1 year at -80°C.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

While preclinical data suggests various benefits, Pomiferin's safety as a cosmetic ingredient has not been reviewed by major regulatory bodies such as CIR, SCCS, or FDA, and there is no specified maximum concentration for topical use.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Pomiferin presents as a highly promising ingredient for anti-aging and skin health formulations, backed by robust in vitro and ex vivo data demonstrating significant ECM stimulation, antioxidant, and anti-inflammatory benefits, though further regulatory review is needed for human topical safety.

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