Science
Mechanism of Action
As an occlusive agent, POLYURETHANE-47 forms a protective, flexible film on the skin's surface. This barrier mechanism is instrumental in significantly reducing transepidermal water loss (TEWL), thereby improving and maintaining skin hydration. The general class of polyurethanes has also demonstrated utility in applications such as wound healing, where their moisture-retaining properties support re-epithelialization processes.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
While a specific optimal pH range for POLYURETHANE-47 stability is not explicitly defined, the pH of formulation systems is generally critical for polyurethane integrity. These polymers can be susceptible to hydrolysis, particularly under acidic conditions (e.g., pH 4.0-6.5), though they typically maintain stability at physiological pH. POLYURETHANE-47 is stable but combustible and incompatible with strong oxidizing agents.
Conflicts
- strong oxidizing agents
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has assessed POLYURETHANE-47, along with 65 other polyurethane ingredients, concluding their safety in cosmetic applications when formulated to be non-sensitizing. This safety determination is based on the absence of detectable residual isocyanate or other monomeric components. It is important to note that while diisocyanates, used in polyurethane synthesis, can cause occupational health issues, the CIR's conclusion for cosmetic ingredients relies on the strict absence of these detectable residuals. The FDA's regulatory framework for polyurethane resins in food-contact adhesives provides a broader context for the material but does not directly establish cosmetic ingredient status for POLYURETHANE-47.
Your Skin
Skin Compatibility
Our Assessment
Verdict
POLYURETHANE-47 is a valuable ingredient for enhancing skin hydration through its occlusive film-forming properties, safely reducing transepidermal water loss as deemed by expert panels.
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References
Sources