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Moumoujus

POLYQUATERNIUM-51.

Valuable CAS 125275-25-4 / FILM FORMING, SKIN CONDITIONING

A synthetic, biomimetic polymer, Polyquaternium-51 possesses amphiphilic properties that closely resemble the natural phospholipids found in skin cell membranes. It functions as an advanced skin conditioning agent, humectant, and film former, engineered to enhance skin hydration and barrier integrity.

Summary

Film forming Skin conditioning Humectant Helps reduce irritation Moisturizing Leaves a silky-smooth feel

Science

Mechanism of Action

This ingredient forms a breathable, protective film on the skin's surface, mimicking the phospholipid structure of corneocytes to reduce trans-epidermal water loss (TEWL) and reinforce the skin barrier. Its humectant capabilities draw and retain moisture, effectively increasing skin hydration, mitigating dryness, and helping to soothe irritation often caused by surfactants.

Research

Clinical Evidence

High confidence
Effective range 0.02–5%
Optimal

Effective concentrations vary, with 0.02% observed in moisturizers, 0.021-0.05% in eye makeup, and up to 5% for general skin conditioning and film-forming benefits. For skin products, a general safety guideline suggests not exceeding 0.5%, though higher levels up to 5% are recommended by some manufacturers for cosmetic applications.

Key findings

  1. 01 Studies indicate effective usage levels for skin conditioning and film-forming properties range from 0.5% to 5%.
  2. 02 Specific applications include 0.02% in moisturizers and 0.021-0.05% in eye makeup formulations for targeted benefits.
  3. 03 The ingredient has demonstrated negative results in a human repeated insult patch test at 0.12% in a serum, and in a guinea pig maximization test up to 100%, suggesting a low potential for sensitization.

Transparency

Dusting Analysis

Not commonly dusted

Polyquaternium-51 is typically used as a dissolved ingredient in formulations and is not associated with dusting concerns.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Exhibits robust stability across a broad pH range and demonstrates good compatibility with electrolytes. It can be seamlessly integrated into both water and emulsion phases, suitable for both hot and cold processing methods.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
5%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel indicates Polyquaternium-51 is safe as used, with a maximum concentration of 5%. A draft report, following an 'Insufficient Data Announcement,' included negative sensitization results from both guinea pig maximization tests (up to 100%) and human repeated insult patch tests (0.12% in serum). It is generally well-tolerated and rarely causes allergic reactions or skin irritation.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Polyquaternium-51 is a valuable, biomimetic ingredient that significantly enhances skin hydration and barrier function with a high safety profile, making it suitable for all skin types across a wide range of cosmetic applications.

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