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Moumoujus

POLYPEPTIDE-1.

Valuable CAS - / SKIN CONDITIONING

POLYPEPTIDE-1, also known as SH-Polypeptide-1 or Basic Fibroblast Growth Factor (bFGF), is a potent single-chain polypeptide crucial for skin renewal and repair. It actively supports fibroblast proliferation and enhances the synthesis of vital structural proteins, collagen and elastin, contributing to a more resilient and youthful complexion.

Summary

Skin conditioning Cell-signaling Skin renewal Skin repair Collagen synthesis booster Elastin synthesis booster Firming Elasticity enhancement Cell turnover enhancement Hyaluronic acid synthesis booster Brightening Even tone improvement

Science

Mechanism of Action

This growth factor acts by stimulating fibroblast proliferation, the primary cells responsible for producing collagen and elastin, thereby reinforcing the skin's structural integrity. It concurrently accelerates cell turnover and regeneration, facilitating the removal of senescent cells and promoting the generation of new, healthy skin cells for a smoother, brighter, and more uniform skin tone. Furthermore, POLYPEPTIDE-1 enhances endogenous hyaluronic acid production and modulates molecular pathways involved in blood vessel development and melanocyte migration, supporting overall skin health and potentially re-pigmentation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 6
0 7 14

Stability

POLYPEPTIDE-1, like many polypeptides, exhibits reduced stability in solution compared to its lyophilized form. Optimal stability for liquid formulations is observed within a narrow pH range of 5.0 to 6.0. Its relatively large molecular weight (17.25 kDa) often necessitates advanced delivery systems, such as liposomes or PLGA-coated nanoparticles, to enhance its stability, improve skin penetration, and optimize topical efficacy.

Conflicts

  • Exposure to mismatched pH levels or inappropriate solvent conditions, leading to potential precipitation, reduced solubility, or protein denaturation.
  • Interaction with other peptides that may either directly chemically interfere or possess opposing biological mechanisms, potentially neutralizing or altering their individual activities.
  • Combination with strong reducing agents or peptides known for redox sensitivity (e.g., certain copper peptides) without prior verification of compatibility, which could compromise peptide integrity or function.
  • Conditions promoting protein aggregation, which can lead to diminished stability and potential unwanted immunogenic responses.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not specifically reviewed POLYPEPTIDE-1, and no maximum concentration for safe use has been established by regulatory bodies like CIR, SCCS, or FDA. However, SH-Polypeptide-1 is not listed on EWG's restricted or unacceptable lists, and general assessments suggest many proteins and peptides derived from tissue or plants are considered safe for cosmetic applications.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

POLYPEPTIDE-1 is a valuable biomimetic signal that significantly supports the skin's natural repair and renewal processes by boosting collagen, elastin, and hyaluronic acid production, leading to a firmer, smoother, and more resilient complexion.

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