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POLYGLYCERYL-2 TETRAISOSTEARATE.

Valuable CAS 121440-30-0 / EMULSION STABILISING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SURFACTANT - CLEANSING

Polyglyceryl-2 Tetraisostearate is a precision ester ingredient serving multiple functions in skincare, notably enhancing skin hydration and optimizing product texture. It functions as an effective emollient, establishing a protective barrier, and as a proficient emulsifier, stabilizing complex formulations.

Summary

Emollient Emulsifier Surfactant Skin Conditioning Agent Barrier Strengthening Pigment Wetting Agent Pigment Dispersing Agent

Science

Mechanism of Action

This ingredient interacts with the skin by filling the intercellular lipid gaps within the stratum corneum, creating a visibly smoother surface and forming a protective film to significantly reduce transepidermal water loss. It actively strengthens the skin's intrinsic barrier function, promoting enhanced moisture retention. Beyond skin benefits, it acts as an emulsifier to homogenize disparate oil and water phases, yielding a stable and uniform product consistency. Its surfactant properties also contribute to gentle cleansing by reducing surface tension and facilitating the removal of impurities.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Polyglyceryl-2 Tetraisostearate exhibits remarkable stability against oxidation, which contributes to the longevity and integrity of formulations. It actively improves overall product stability and texture, and demonstrates good dispersibility with pigments, which is advantageous for color cosmetics and sunscreens.

Conflicts

  • May potentially exacerbate fungal acne (Malassezia folliculitis) in susceptible individuals due to its fatty acid composition, prompting avoidance for those with this condition.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
7%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that polyglyceryl fatty acid esters, including Polyglyceryl-2 Tetraisostearate, are safe for use in cosmetics at their current concentrations and practices, provided the final product formulation is non-irritating. Paula's Choice cites a maximum concentration of 7% by the CIR panel. It is generally regarded as a mild ingredient, typically well-tolerated across most skin types, and carries a low risk of allergic reactions. A preliminary patch test is recommended for individuals with highly sensitive skin prior to full application.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Polyglyceryl-2 Tetraisostearate is a valuable, mild ingredient that simultaneously enhances skin barrier function and hydration while improving product stability and texture across a wide range of cosmetic formulations.

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