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POLYGLYCERYL-10 ISOSTEARATE.

Valuable CAS 133738-23-5 / SKIN CONDITIONING

Polyglyceryl-10 Isostearate is a multifunctional, plant-derived ester functioning as an effective emulsifier, skin conditioner, and mild surfactant. It meticulously blends immiscible liquids in formulations, enhancing stability and texture. Beyond its structural role, it provides notable hydrating and emollient benefits to the skin.

Summary

emulsifying skin conditioning emollient surfactant

Science

Mechanism of Action

This ingredient primarily acts as an oil-in-water (O/W) emulsifier, effectively blending disparate water and oil components to create stable and uniform cosmetic formulations, thereby preventing phase separation. As a surfactant, it reduces surface tension, aiding in the gentle removal of dirt and oil from the skin while concurrently supporting the integrity of the skin's moisture barrier. Its emollient properties allow it to soften and smooth the skin's surface by forming a lightweight, protective film that locks in moisture, thereby enhancing hydration and reducing transepidermal water loss. Additionally, it may facilitate improved absorption of other active ingredients within the formulation.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Aqueous patch tests at concentrations ranging from 0.1% to 1% reported no reactions, indicating a gentle profile.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Polyglyceryl-10 Isostearate, characterized by an HLB value of approximately 13.5, functions as an efficient oil-in-water emulsifier, vital for achieving robust product texture and stability across formulations such as creams and lotions. It demonstrates excellent dispersibility in water and solubility in various oils and specific organic solvents. Its notable hygroscopic nature allows it to form a unique cyclopolymerized structure within water-containing formulas, effectively locking in moisture and ensuring smooth consistency and optimal spreadability. This ingredient is well-suited for natural formulations due to its broad compatibility with numerous oils.

Synergies

  • Compatible with a wide array of oils for enhanced formulation stability and sensory characteristics.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel concluded that Polyglyceryl-10 Isostearate, among a broader group of polyglyceryl fatty acid esters, is safe for use in cosmetics under current practices and concentrations, provided formulations are non-irritating. While no specific maximum concentration for Polyglyceryl-10 Isostearate has been definitively set, related polyglyceryl esters have been reported safe for use in leave-on products at concentrations up to 40%. Aqueous patch tests conducted at 0.1-1% showed no reported adverse reactions. No specific SCCS opinion or further FDA approval status beyond its listing in FDA GSRS was identified.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Polyglyceryl-10 Isostearate is a valuable ingredient, prized for its exceptional emulsifying capabilities, diverse skin-conditioning benefits including hydration and emollience, and a thoroughly documented low irritancy and comedogenicity profile suitable for all skin types.

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