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POLYGLYCERIN-6.

Valuable CAS 36675-34-0 / HUMECTANT

Polyglycerin-6 is a highly effective humectant and skin conditioning agent, meticulously designed to draw and retain moisture, promoting a plump, soft, and smooth skin texture. It also supports the skin's protective barrier and can enhance formula stability as a solubilizer.

Humectant Moisturizer Skin Conditioning Agent Solubilizer Barrier Support

Science

This ingredient functions primarily as a humectant, leveraging its hygroscopic nature to attract water from the atmosphere and deeper epidermal layers, thereby boosting skin hydration and elasticity. Its larger molecular structure compared to glycerin may facilitate a slower, more sustained moisture release, contributing to prolonged skin conditioning. Polyglycerin-6 also plays a role in fortifying the skin's natural barrier, mitigating transepidermal water loss (TEWL), and serves as a versatile solubilizer, improving the stability and texture of complex cosmetic formulations.


Research

Low confidence
Effective range 2–10%
Optimal

N/A

Key findings

  1. 01 Reported usage levels in skincare products typically range from 2% to 10%, indicating its role in hydration within these concentrations. No specific independent clinical efficacy studies at these precise concentrations were identified.

Transparency

Not commonly dusted

No data available in the provided research to suggest 'dusting' concerns.


The Formula

Solubility
Water
Optimal pH 3.8 – 8
0 7 14

Stability

Polyglycerin-6 exhibits exceptional water solubility, exceeding 1000 g/L, attributed to its hydrophilic structure. It maintains stability and can be synthesized within an aqueous pH range of 3.8 to 8.0. Its balanced viscosity and emulsifying properties are beneficial for stabilizing oil-in-water emulsions, ensuring formulation integrity.

Synergies

  • Acts as a solubilizer for other cosmetic ingredients, enhancing overall formulation stability and texture.
  • Effective as an emulsifier in oil-in-water systems.

Safety

CIR Status
Safe as used
Max tested
10%
Sensitization risk Low

The Expert Panel for Cosmetic Ingredient Safety (CIR) concluded in a September 2023 report that Polyglycerin-6 is safe for cosmetic use within current practices and concentrations, considering its likely breakdown into the already deemed safe glycerin. It is listed in the FDA Global Substance Registration System (GSRS). Acute eye irritation tests indicate slight to minimal, quickly resolving irritation, and its inclusion in sensitive skin formulations further supports its low sensitization potential.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Valuable

Polyglycerin-6 is a valuable, safe, and versatile ingredient, offering robust hydration, barrier support, and formulation benefits for all skin types, including sensitive skin.


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