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Moumoujus

POLYGLYCERIN-4.

Valuable CAS 56491-53-3 / HUMECTANT

A versatile polyglycerol derivative, POLYGLYCERIN-4 acts as an effective skin conditioning agent, significantly enhancing hydration and reinforcing the skin's barrier function. It also performs as an essential emulsifier and solubilizer, improving product formulation stability and texture.

Summary

Skin Conditioning Emulsifying Hydrating Agent Emollient Barrier Strengthening Penetration Enhancer Solubilizer

Science

Mechanism of Action

This ingredient operates by forming a protective film on the skin's surface, which demonstrably reduces transepidermal water loss (TEWL) and strengthens the epidermal barrier, leading to prolonged hydration and enhanced skin elasticity. Its emollient properties provide a smooth, supple skin feel. Furthermore, POLYGLYCERIN-4 can facilitate the dermal penetration of other active ingredients. In cosmetic formulations, it functions as a surfactant, lowering surface tension to effectively blend immiscible oil and water components, and solubilize oil-loving substances within aqueous systems.

Research

Clinical Evidence

High confidence
Effective range 0.5–1.5%
Optimal

1.5%

Key findings

  1. 01 CIR Expert Panel Review

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 5.5 – 10
0 7 14

Stability

POLYGLYCERIN-4 demonstrates robust stability across a pH range of 5.5 to 10.0. It exhibits broad compatibility with a diverse array of formulation components, including electrolytes (e.g., NaCl, MgSO4), various oils (vegetable and mineral), silicones, esters, UV filters, pigments, and common rheology modifiers such as carbomers, xanthan gums, acrylic biopolymers, and cellulose derivatives. It can be efficiently incorporated into the water phase and is suitable for cold processing methods.

Synergies

  • Electrolytes (e.g., NaCl, MgSO4)
  • Vegetable oils
  • Mineral oils
  • Silicones
  • Esters
  • UV filters
  • Pigments
  • Carbomers
  • Xanthan gums
  • Acrylic biopolymers
  • Cellulose derivatives

Conflicts

  • Ingredients whose safety is contingent on minimal dermal absorption, due to potential increased penetration.
  • Toxic chemicals, requiring careful consideration due to potential for enhanced absorption.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
1.5%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel concluded in 2023 that polyglyceryl fatty acid esters, including those relevant to POLYGLYCERIN-4, are safe for cosmetic use when formulated to be non-irritating. Specifically, it is deemed safe at concentrations up to 1.5% in both leave-on and rinse-off products. Regulatory bodies such as the European Union's Cosmetics Regulation also approve its use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Medium

Our Assessment

Verdict

Valuable

POLYGLYCERIN-4 is a valuable multi-functional ingredient, supporting skin hydration and barrier integrity while also serving as an excellent emulsifier and solubilizer for diverse formulations, suitable for all skin types.

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