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Moumoujus

POLYGALA TENUIFOLIA ROOT EXTRACT.

Insufficient Data CAS 94167-09-6 / SKIN CONDITIONING

Derived from the root of Polygala tenuifolia, this botanical extract is recognized for its multifaceted potential in skincare. It offers significant anti-inflammatory and antioxidant properties, suggesting benefits for overall skin conditioning and managing reactivity. Its broad action pathways indicate a promising role in supporting skin health.

Summary

anti-inflammatory antioxidant antibacterial skin conditioning brightening anti-aging uv protection

Science

Mechanism of Action

Polygala Tenuifolia Root Extract operates through a complex network of pathways to modulate skin health. It exhibits anti-inflammatory effects by inhibiting inflammatory mediators such as HMGB1 and LPS-induced nitric oxide (NO) production, alongside downregulating iNOS and COX-2 protein levels. The extract also suppresses immune responses by inhibiting TLR4 and Myd-88 expression, blocking NF-κB translocation, and modulating MAPKs and JNK signaling pathways. Furthermore, it contributes to antioxidant defense by inducing Nrf2/HO-1 signaling and offers antibacterial benefits, collectively promoting comprehensive skin conditioning.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Inhibited the downstream inflammatory response triggered by HMGB1 in an in vitro model, demonstrating potent anti-inflammatory action at a concentration of 49.46 µg/mL.
  2. 02 Significantly reduced LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages by 32.66% at a concentration of 100 µg/mL, highlighting its anti-inflammatory capacity.
  3. 03 Specific compounds isolated from the extract demonstrated significant inhibitory effects on LPS-induced NO production in BV2 microglia cells, with effective concentrations ranging from 10.0-100.0 µM.

Transparency

Dusting Analysis

Not commonly dusted

Information regarding the practice or threshold for 'dusting' this ingredient in cosmetic formulations is not available within the provided research data.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The extract contains triterpenoid saponins, oligosaccharide esters, and xanthones. Its solubility in both water and alcohol (e.g., methanol, ethanol) indicates versatility in formulation, suggesting stability across various polar solvent systems.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Preclinical studies in rats and beagle dogs indicated low acute oral toxicity (up to 2 g/kg) and subchronic toxicity (up to 1,000 mg/kg/day) in these animal models. However, the Cosmetic Ingredient Review (CIR) and Scientific Committee on Consumer Safety (SCCS) have not formally assessed this ingredient for cosmetic use, and regulatory information for its use as a nutraceutical is also limited. Therefore, specific cosmetic safety parameters for human use, including sensitization risk and pregnancy safety, remain unestablished.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Polygala Tenuifolia Root Extract demonstrates compelling in vitro anti-inflammatory and antioxidant potential across multiple biological pathways, suggesting significant benefits for sensitive and compromised skin; however, further clinical efficacy data on human skin and formal cosmetic safety assessments are required for a definitive precision rating.

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